Protein Alignment Cyp4d21 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 126/492 - (25%)
• Similarity: 239/492 - (48%)
• Gaps: 47/492 - (9%)

  Fly     2 WILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGN---GLQALTLRPENFIQRFGDY 63
            |:|:..:::::.:...:|.|     .|:|..|.||..:|.:|.   .|:.|........:::|:.
Human    12 WVLVATSLVLLYIYGTHSHK-----LFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM 71

  Fly    64 FNKY-GKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTSR 127
            :..| |:...|.|:...:|.|..:|...|:.::...|..       ..||...|..:...:|...
Human    72 WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGP-------MGFLKSALSFAEDEEWKRI 129

  Fly   128 RKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVN 192
            |.:|:|||.....:..|.|:.:...::|..|:..|:....::|..|.....:||.|.|..||.::
Human   130 RTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLD 194

  Fly   193 AQNEPNFPYTKALKSVVYIE--SKRLASVSMRYNWLFPLAAPLVYRRLQ-----KDIA-IMQDFT 249
            :.|.|..|:.|.:|.::.::  ...|..:|     |||...| |:..|.     ||:. .:::..
Human   195 SLNNPQDPFLKNMKKLLKLDFLDPFLLLIS-----LFPFLTP-VFEALNIGLFPKDVTHFLKNSI 253

  Fly   250 DKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFI 314
            :::...|....::.|.| .::.:|...:.              :.|..:|.|||:::..:..:.|
Human   254 ERMKESRLKDKQKHRVD-FFQQMIDSQNS--------------KETKSHKALSDLELVAQSIIII 303

  Fly   315 FAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRL 379
            ||..|||::.:...::.::.||.||:.:.||:.:|| |: .|.||...|::::|||.|:.||:||
Human   304 FAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PN-KAPVTYDALVQMEYLDMVVNETLRL 366

  Fly   380 HPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPL 444
            .|.|..:.|...:|::|..:.||...::::..|.::.||:|:.:|..|.||.....|...:....
Human   367 FPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLY 431

  Fly   445 AYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481
            .||||.:||:||||.:||...:|..:.:.::::...|
Human   432 RYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	111/422 (26%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	113/432 (26%)