DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006524820.1	Gene:	Cyp4f40 / 631304	MGIID:	3645508	Length:	551	Species:	Mus musculus

Alignment Length:	527	Identity:	167/527 - (31%)
Similarity:	265/527 - (50%)	Gaps:	38/527 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WILLG-------IAVLIMTLVWDNSRKQWRVNT-FEKSRILGPFTIPIVGN---GLQALTLRPEN 55
            |:.||       :...::.:.|..:|...::.| :.|.:.|..|..|...|   |...::...|.
Mouse    35 WLGLGPMSASPWLLFFLVGISWFLARFLTQLYTLYAKCQRLCGFPQPPKKNWFWGHLGMSPPTEE 99

  Fly    56 FIQRFGDYFNKYGKTFRLWILGEC--LIYTKDLKYFESILSSSTLL--KKAHLYRFLRDFLGDGL 116
            .:::..:....|.:.|..| ||..  ||.........|:||:|..:  |....|.||:.:|||||
Mouse   100 GMKQVTELVTTYPQGFMTW-LGPIVPLITLCHPDIIRSVLSASAAVAPKDDIFYSFLKPWLGDGL 163

  Fly   117 LLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEK-LKNYADGKTCVDLFKFVSLEALD 180
            |:|.|:||...|::|.|||||..|:.:|:|.:.::.||..| |:..:.|.|.:::|:.:||..||
Mouse   164 LVSAGDKWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGGSTRLNMFENISLMTLD 228

  Fly   181 VTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIM 245
            ...:.......|.|.:|: .|..|:..:..:..||...:.|..:.|:.|....:  |..|...::
Mouse   229 TLQKCVFSFNSNCQEKPS-QYIAAILELSTLAVKRNEQLLMHVDLLYRLTPDGM--RFYKACRLV 290

  Fly   246 QDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----ILLQATIDNKPLSDVDI 306
            .||||.||:|||..|.:..          |||.|..|||...||    :||....|.|.|||.||
Mouse   291 HDFTDAVIQERRRTLLKHG----------GDDIIKAKAKSKTLDFIDVLLLTKDEDGKELSDEDI 345

  Fly   307 REEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDC 371
            |.|.|.|:|.|.|||.||:|..|:.::|||:.||...:|:..:|.......:....|.:|.:|..
Mouse   346 RAEADTFMFRGHDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEIEWDDLAQLPFLTM 410

  Fly   372 VIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMD 434
            .|||::||||||.::.|...:|:.:  |.| ||.....::..:..:.:|..:.||.|:.|.|: |
Mouse   411 CIKESLRLHPPVTMVSRCCTQDISLPDGRI-IPKGVICIINIFGTHHNPTVWRDPEVYDPFRF-D 473

  Fly   435 MKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFILSSSTG 499
            .:......||::||||:||:|||||.||..:||..::..:..:.:||...:.:.....||.:..|
Mouse   474 PENIQARSPLSFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPELILRAEGG 538

  Fly   500 NNVGLKP 506
            ..:.::|
Mouse   539 LWLRVEP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	154/460 (33%)
Cyp4f40	XP_006524820.1	p450	79..542	CDD:365848	157/478 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750