Protein Alignment Cyp4d21 and cyp46a1.3

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001027517.1
• Gene: cyp46a1.3 / 613109
• XenbaseID: XB-GENE-969052
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 562
• Identity: 150/562 - (26%)
• Similarity: 248/562 - (44%)
• Gaps: 116/562 - (20%)

  Fly     1 MWILLG-IAVLIMTLV-----------------WDNSRKQWRVNTFEKSRILGPFTIP----IVG 43
            :|.|:| .|:|::.|:                 :|:              |.||   |    .:|
 Frog     3 LWALIGWAALLLLALILICFLLFSGYIHYIHMKYDH--------------IPGP---PRDSFFLG 50

  Fly    44 NGLQALTLRPENFI--QRFGDYFNKYGKTFRLWILGECLI----------------YTKDLKYFE 90
            :....|.|...|.:  ..|..:..|||...|:..|...:|                |:|| |:::
 Frog    51 HSPTMLRLMKNNLLMYDHFLGWVQKYGPVVRINGLHRVIILVVSPEAVKELLMSPKYSKD-KFYD 114

  Fly    91 SILSSSTLLKKAHLYRFLRDFLGDGLLLSTG-NKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIM 154
            .|.:           .|...|:|.||:.... :.|..:|:::.|||....|...:...:..:..:
 Frog   115 VIAN-----------MFGVRFMGKGLVTDRDYDHWHKQRRIMDPAFSRTYLMGLMGPFNEKAEEL 168

  Fly   155 VEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASV 219
            :|||...||||..:.:...:|...|||..:.|.|:::|:.|:...|:.||: |:|......:.:.
 Frog   169 MEKLMEKADGKCEIKMHDMLSRLTLDVIGKVAFGMELNSLNDDLTPFPKAI-SLVMKGIVEMRNP 232

  Fly   220 SMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAK 284
            .:||:    ||.....|::|:.|.:::. |.|...|||   ::...||...|
 Frog   233 MVRYS----LAKRGFIRKVQESIRLLRQ-TGKECIERR---QKQIQDGEEIP------------- 276

  Fly   285 MTLLDILLQATIDNKPLSDVDIREEVD---------VFIFAGDDTTTSGVSHALHAISRHPKVQE 340
               :|||.|.      |....:.||.|         .|..||.:||.:.:|..:..:.|:|::.|
 Frog   277 ---VDILTQI------LKGAAMEEECDPEILLDNFVTFFIAGQETTANQLSFVVMELGRNPEILE 332

  Fly   341 CIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNT 405
            ....|:..|:|...|  :....|.:|:||..|:|||:||:|..|...|.:.||:.|..:.:|.|.
 Frog   333 KAQAEIDEVIGSKRD--IEYEDLGKLQYLSQVLKETLRLYPTAPGTSRGLTEDMVIDGVKVPENV 395

  Fly   406 SILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALI 470
            :|:|..|.:.|..:|:.|||.|.|:|:   ...:..|..:|.|||.||::||||.|:.::.|.::
 Frog   396 TIMLNSYIMGRMEQYYSDPLTFNPDRF---SPDAPKPYYSYFPFSLGPRSCIGQVFSQMEAKVVM 457

  Fly   471 SKVIRHYEL-LPLGADLKATYTFILSSSTGNNVGLKPRTRVK 511
            :|:::.||. |..|...|...|..|....|....|:|||..|
 Frog   458 AKLLQRYEFELAEGQSFKILDTGTLRPLDGVICRLRPRTSKK 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	127/460 (28%)
cyp46a1.3	NP_001027517.1	CYP46A1-like	66..490	CDD:410706	130/471 (28%)