Protein Alignment Cyp4d21 and CYP26B1

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 124/533 - (23%)
• Similarity: 222/533 - (41%)
• Gaps: 100/533 - (18%)

  Fly     5 LGIAVLIMTLVWDNSRKQWRVN---TFEKSRIL----GPFTIPIV---------GNGLQALTLRP 53
            |...::.:||:...|::.|::.   |.:||..|    |....|::         |:|.|  :.|.
Human    15 LAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQ--SSRR 77

  Fly    54 ENFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLL 118
            |           |||..|:..:||..||.....:....||.....|......|..|..||...:.
Human    78 E-----------KYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVS 131

  Fly   119 -STGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVT 182
             |.|:...::|||.:..|..:.||::   :.:...::.:.|:.::.....:::::    ||..:|
Human   132 NSIGDIHRNKRKVFSKIFSHEALESY---LPKIQLVIQDTLRAWSSHPEAINVYQ----EAQKLT 189

  Fly   183 TETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRY-NWLFPLAAPLV---YRRLQKDIA 243
            ...|:.|.:..             |:...:...|..|..:: :.:|.|...|.   |||..:...
Human   190 FRMAIRVLLGF-------------SIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQ 241

  Fly   244 IMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDN-KPLSDVDIR 307
            |:|...:|.|||:....:                   ||..:..||:|::::.:: |.::..:::
Human   242 ILQKGLEKAIREKLQCTQ-------------------GKDYLDALDLLIESSKEHGKEMTMQELK 287

  Fly   308 EEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVS--VL---GPDPDASVTQTKLLELK 367
            :.....|||...||.|..:..:..:.:||.|.|.:.:||.:  :|   |...:.::....|..|:
Human   288 DGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLR 352

  Fly   368 YLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPE----YFPDPLVFK 428
            ||||||||.|||..|:....|.:.:..::....||...|::    |..||..    .|.|..||.
Human   353 YLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVM----YSIRDTHDTAPVFKDVNVFD 413

  Fly   429 PERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFI 493
            |:|:...::........|:||..|.:.|:|:..|.|.:|.             |..:|.:|..|.
Human   414 PDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKV-------------LAVELASTSRFE 465

  Fly   494 LSSSTGNNVGLKP 506
            |::.|...:.|.|
Human   466 LATRTFPRITLVP 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	104/448 (23%)
CYP26B1	NP_063938.1	CYP26B1	60..490	CDD:410730	113/488 (23%)