Protein Alignment Cyp4d21 and Cyp3a41a

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_059092.2
• Gene: Cyp3a41a / 53973
• MGIID: 1858451
• Length: 504
• Species: Mus musculus
• Alignment Length: 508
• Identity: 135/508 - (26%)
• Similarity: 246/508 - (48%)
• Gaps: 79/508 - (15%)

  Fly     2 WILLGIAVLIMTLVWDNSRKQWRVNT-----FEKSRILGPFTIPIVGNGLQALTLRPENFIQRFG 61
            |:||.|.::::          :|..|     |:|..|.||..:|.:|..|        |:.:...
Mouse    12 WVLLAIILVLL----------YRYGTRTHGLFKKQGIPGPKPLPFLGTVL--------NYYKGLW 58

  Fly    62 DY----FNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDF-----LGDGLL 117
            .:    :.|||||:.|:.....|....|.:..:::|.....    .::...|:|     :...:.
Mouse    59 KFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECF----SVFTNRREFGPVGIMSKAIS 119

  Fly   118 LSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVT 182
            :|...:|...|.:|:|.|....|:....::::...|:|:.|...|:....|.:...:...::||.
Mouse   120 ISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVTMKDVLGAYSIDVI 184

  Fly   183 TETAMGVQVNAQNEPNFPYTKALKSVVYIE--SKRLASVSMRYNWLFPLAAPLVYRRLQ-----K 240
            |.|:.||.|::.|.|..|:.:..|.::.::  ...:.||.     |||...| ||..|.     |
Mouse   185 TSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVV-----LFPFLTP-VYEMLNICMFPK 243

  Fly   241 D-IAIMQDFTDKVIRERRAILERARADGTYKPLIMG------DDDIGGKAKMTLLDILLQATIDN 298
            | |...:.|.:::...|....::.|.|  :..|:|.      |.|                  .:
Mouse   244 DSIEFFKKFVNRMKESRLDSKQKHRVD--FLQLMMNAHNNSKDKD------------------SH 288

  Fly   299 KPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKL 363
            |.|||::|..:..||||||.:||:|.:|..|:.::.||.:|:.:.||:...| |: .|..|...:
Mouse   289 KALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETL-PN-KAPPTYDTV 351

  Fly   364 LELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFK 428
            :|::|||.|:.||:||:|....|.|:..:|:::..:.||..:::::..|.::.||:::|:|..|:
Mouse   352 MEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQ 416

  Fly   429 PERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481
            |||: ..:...:..|..|:||..||:||||.:||.:.||..::||::::...|
Mouse   417 PERF-SKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQP 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	118/433 (27%)
Cyp3a41a	NP_059092.2	CYP3A	67..493	CDD:410743	120/435 (28%)