DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	125/522 - (23%)
Similarity:	216/522 - (41%)	Gaps:	107/522 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IAVLIMTLVWDNSRKQWRVNT---FEKSRILG--PFTIPIVGN--GLQALTLRPENFIQRFGDYF 64
            :|:|::.|    :...|.|.|   :...|.:|  |...| |||  |.:    :.::||......:
  Fly     5 VALLLIAL----AVGFWFVRTRYSYWTRRGIGSEPARFP-VGNMEGFR----KNKHFIDIVTPIY 60

  Fly    65 NKY---GKTFR-LWILGECLIYTKDLKYFESIL-SSSTLLKKAHLYRFLRDF-LGDGLLLSTGNK 123
            .|:   |..|. .:::...::...||:..:.|| ......:...:|...||. |...|....|.|
  Fly    61 EKFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRIDGPK 125

  Fly   124 WTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTC--VDLFKFVSLEALDVTTETA 186
            |...|:.::|.|....::.....:......:.:.....||...|  :::...::....||....|
  Fly   126 WRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCA 190

  Fly   187 MGVQVNAQNEPN----------FPYTKALKSV-VYIESKRLASVSMRYNWLFP-LAAPLVYRRLQ 239
            .||:.|....|.          |...:..|.| .:|||             || :|..|..|::.
  Fly   191 FGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIES-------------FPEVARFLRMRQIH 242

  Fly   240 KDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDV 304
            :||.   ||...::||  .:.:|...               |..:...:::|    |:.|...::
  Fly   243 QDIT---DFYVGIVRE--TVKQREEQ---------------GIVRSDFMNLL----IEMKQRGEL 283

  Fly   305 DIRE---EVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLEL 366
            .|.|   :..:|..||.||:.|.:..||:.:::.|.:|..:.||:...|... :...|...:.||
  Fly   284 TIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLH-NGEFTYDSMQEL 347

  Fly   367 KYLDCVIKETMRLHPPVPILGR--------------YIPEDLKIGEITIPGNTSILLMPYY-VYR 416
            :|::.||.||:|.:|.:|.|.|              ||.          ||  .:||:|.| ::.
  Fly   348 RYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIE----------PG--QMLLIPVYGIHH 400

  Fly   417 DPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIR--HYEL 479
            ||..:|:|..|.|||:: ....:..|..|::||..||:||||.:|..:|....:..::|  |:.:
  Fly   401 DPALYPEPHKFIPERFL-ADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSV 464

  Fly   480 LP 481
            .|
  Fly   465 CP 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	118/491 (24%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	117/488 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910