DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	492	Identity:	143/492 - (29%)
Similarity:	246/492 - (50%)	Gaps:	47/492 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIP--IVGNGLQALTLRPENFIQRFGDYFNK 66
            |||:.:|::........:||.:.:.::   ..|...|  :.||     ||:.:: :|:......|
Mouse    24 LLGLLLLLLKSAQYYLHRQWLIKSLQQ---FPPAPPPQWLFGN-----TLKDQD-LQQILLCVEK 79

  Fly    67 YGKTFRLWILG---ECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTSRR 128
            :..|:..|:.|   ..:||..|  |.:.||..|. .|....|.|...::|.||||..|.||...|
Mouse    80 FPSTYVRWLWGNHARVVIYDPD--YMKVILGRSD-PKVVRSYSFFAPWIGYGLLLLNGKKWFQHR 141

  Fly   129 KVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVNA 193
            ::|.||||:..|:.:|.||..:..:|::|.:...|....:::::.:||..::...:.|...|.:.
Mouse   142 RMLTPAFHYDILKPYVGIMVDSVHVMLDKWEQLVDQDCPLEIYQDISLMTMETMMKCAFSYQGSV 206

  Fly   194 QNEP---NFPYTKALKSVVYIESKRLASVSMRYNWLFPLAA--PLVYRRLQKDIAIMQDFTDKVI 253
            |.|.   :..|.||::.:.::...|:.:...:.|.::.|::  ...|...|    |....|::||
Mouse   207 QLEDCRNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRSFYHACQ----IAHKHTERVI 267

  Fly   254 RERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQA-TIDNKPLSDVDIREEVDVFIFAG 317
            |.|:|.|:.......::.          |.::..|||||.| |.|.|.|||.|:|.|:|.|:|.|
Mouse   268 RMRKAQLQNEAELEKFRK----------KKRLDFLDILLFAQTEDGKSLSDEDVRAEMDTFMFEG 322

  Fly   318 DDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPP 382
            .:||.||:|...:|::.||:.|:...||:.|:||  ...|||...|.::.|....|||.:||:||
Mouse   323 HNTTASGISWIFYALATHPEHQQRCREEVKSILG--NGTSVTLNHLDQMPYTTMCIKEALRLYPP 385

  Fly   383 VPILGRYIPEDLKIGE-ITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTP--PL 444
            :|...|.:...:...: .::|....:.|..|.::.:|...|:..||.|.|:     ....|  ..
Mouse   386 IPGASRELSSPVTFPDGCSLPKGFLVTLSFYGLHHNPRLRPNAEVFDPSRF-----APGAPRQTH 445

  Fly   445 AYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481
            |::|||:|.:||||::|...::|..::..:..:||||
Mouse   446 AFLPFSAGTRNCIGKQFTMNELKVAVALTLLRFELLP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	137/461 (30%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	135/454 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750