DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	138/493 - (27%)
Similarity:	231/493 - (46%)	Gaps:	53/493 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILLGIAVLI-MTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTL--RPENFIQRFGDYF 64
            :||.:..|. :..:|...|..     |...:|.||..:||:|:.|:.:..  |..:|..:   |.
  Fly     6 LLLAVGALFWIYFLWSRRRLY-----FLMLKIPGPIGLPILGSSLENIITYKRKLSFRTK---YL 62

  Fly    65 NKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKA-HLYRFLRDFLGDGLLLSTGNKWTSRR 128
            ||||.|...|:.....|.|:|.|..|.|.||.....|: |:...:...:|:|||......|..||
  Fly    63 NKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRR 127

  Fly   129 KVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVNA 193
            |...|:|....|.:|..|.|..:.:::..|..|.| |..:|:...:...:..:..:|.||.:|
  Fly   128 KHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVD-KGEIDVVPEMLRWSFKIAAQTTMGSEV-- 189

  Fly   194 QNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLV------YRRLQKD-IAIMQDFTDK 251
            :::.:|      |:...:||..........|.|.||....:      |.:|:.| .:.:|...|.
  Fly   190 KHDEHF------KNGSLVESFESLISHSTLNILMPLVQNRMISKICGYDKLRADNFSRIQKMLDN 248

  Fly   252 VIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFA 316
            |:.::...|.:..:|.....:|....::..|..:|.:                |::.|..:.|.|
  Fly   249 VVNKKVNPLPKTDSDPESNIVINRAMELYRKGDITYM----------------DVKSECCIMIAA 297

  Fly   317 GDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDA---SVTQTKLLELKYLDCVIKETMR 378
            |.||:...|.|||..::.||:.||.::|||..|.   |||   .:|...:.:|.||:.|||||:|
  Fly   298 GYDTSALTVYHALFLLANHPEHQEAVFEELNGVF---PDAGHFGITYPDMQKLDYLERVIKETLR 359

  Fly   379 LHPPVPILGRYIPEDLKIGE-ITIPGNTSILLMPYYVYRDPEYF-PDPLVFKPERWMDMKTTSNT 441
            |.|.:||..|....|:::.. :.||....|.:..::.:|:||.: ||...|.|:.:: .:.....
  Fly   360 LIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFL-AENMEQK 423

  Fly   442 PPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYEL 479
            .|.|||||:.|.:||||.|:|.:..|..:.:::|:|::
  Fly   424 HPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKI 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	131/460 (28%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	131/461 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	6	5.870