DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp313a5

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	124/486 - (25%)
Similarity:	224/486 - (46%)	Gaps:	57/486 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFGDYFNKYGKTFRL 73
            :|.:..:|  ||:::.:...   ::.||...|.:|...:.:.|:.:..::..  .|..||||...
  Fly    13 ILCVYFLW--SRRRFYIMML---KLPGPMGFPFIGLAFEYIRLKRKIRLRTI--LFKIYGKTVLT 70

  Fly    74 WILGECLIYTKDLKYFESILSS------STLLKKAHLYRFLRDFLGDGLLLSTGNKWTSRRKVLA 132
            ||....::.|.:.|..|.|.:|      |:::.||     :...||.|||....|.|..|||:|.
  Fly    71 WIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKA-----ISSCLGLGLLTLKNNHWNERRKLLL 130

  Fly   133 PAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVNAQNEP 197
            |:|....:.:||.:::..:..:|..|..:.||.. ::|...::..:..:..:..||.:|  :|:.
  Fly   131 PSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGD-INLLPELNKWSFKIAAQITMGDEV--RNQA 192

  Fly   198 NFPYTKALKSVVYIESKRLASVSMRYNWLFP--LAAPLVY--RRLQ---KDIAIMQDFTDKVIRE 255
            |:.....|:|  |.....|..:.:...||..  |.....|  |||:   :..|.::|..||.:
  Fly   193 NYQNGNLLES--YKALNNLIPIGVVMPWLRNKYLGKLFSYEKRRLEAATQSNAFIKDIIDKKL-- 253

  Fly   256 RRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFAGDDT 320
                   :..|.:.:|              .|:|.:|. .:....||..|:..|....|||..||
  Fly   254 -------SSTDNSSEP--------------ALIDRILN-LVRIGELSYDDVMGEFSNIIFAASDT 296

  Fly   321 TTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPI 385
            .:..|::.|..::..||.|:.::|||..|.....:...:...|.:|..||.|:.|||||.|.||:
  Fly   297 LSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDRVLHETMRLIPAVPL 361

  Fly   386 LGRYIPEDLKIGE-ITIPGNTSILLMPYYVYRDPEYF-PDPLVFKPERWMDMKTTSNTPPLAYIP 448
            |.|.....:::.. ..||...::::..::.:|:.:.: |....|.|:.::.....:. ||.:|:|
  Fly   362 LIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRAR-PPYSYLP 425

  Fly   449 FSSGPKNCIGQKFANLQMKALISKVIRHYEL 479
            ||.|.|.|:|.|.:.:..|..::|::|:|.|
  Fly   426 FSKGKKTCLGWKLSLISAKLALAKILRNYML 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	120/460 (26%)
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	120/461 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.870