Protein Alignment Cyp4d21 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 152/477 - (31%)
• Similarity: 240/477 - (50%)
• Gaps: 57/477 - (11%)

  Fly    72 RLWILG---------ECLIYTKDL------------------------KYFESILSSSTLL--KK 101
            |.|.||         |.|:||:.|                        .|.:.:|.:...:  |.
Human    57 RNWFLGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKD 121

  Fly   102 AHLYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYA-DGK 165
            ...|.||:.:||||||||.|.||:..|::|.|||||..|:.:::|.:.:..||..|.:..| :|.
Human   122 KVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGS 186

  Fly   166 TCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLA 230
            ..:|:|:.:||..||...:.......:.|.:|: .|..|:..:..:.:||...:.:..::|:.|.
Human   187 ARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLT 250

  Fly   231 APLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----IL 291
            ..  .:|.::...::.||||.||:|||..|.   :.|.       ||.:..|||...||    :|
Human   251 PD--GQRFRRACRLVHDFTDAVIQERRRTLP---SQGV-------DDFLQAKAKSKTLDFIDVLL 303

  Fly   292 LQATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDA 356
            |....|.|.|||.|||.|.|.|:|.|.|||.||:|..|:.:::||:.||...:|:..:|......
Human   304 LSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPK 368

  Fly   357 SVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPE 419
            .:....|.:|.:|...|||::|||||||.:.|...:|:.:  |.: ||.....|:..:..:.:|.
Human   369 EIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRV-IPKGIICLISVFGTHHNPA 432

  Fly   420 YFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGA 484
            .:|||.|:.|.|: |.|......|||:||||:||:|||||.||..:||.::...:..:.:||...
Human   433 VWPDPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHT 496

  Fly   485 DLKATYTFILSSSTGNNVGLKP 506
            :.:.....:|.:..|..:.::|
Human   497 EPRRKPELVLRAEGGLWLRVEP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	151/471 (32%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	146/455 (32%)