DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4p3

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	160/537 - (29%)
Similarity:	258/537 - (48%)	Gaps:	56/537 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPI-VGNGLQALTLRP--------ENF 56
            :|::....|||          ||.........|||.|...| ..||....::.|        .|.
  Fly     4 LWLVGAFIVLI----------QWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANS 58

  Fly    57 IQRFG-----------DYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRD 110
            ...:|           |...|.||::..:.:|..:....|....|.:|:...|:.|..:|.||..
  Fly    59 FDLYGKDHSGVFEHSRDCAKKLGKSYAEYAMGTAIYNVIDADSAERVLNDPNLINKGTIYDFLHP 123

  Fly   111 FLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVS 175
            ||..|||.|||.||.:|||:|:|.|||..|..|.||....|...:|:.|  .:.:..:.|.:.:.
  Fly   124 FLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQFK--GNDEAIISLNEVIP 186

  Fly   176 LEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQK 240
            ...|:...||||||:::...|....|.:..:.:.....:|:::..:..:.||.:.|       :|
  Fly   187 RFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFA-------EK 244

  Fly   241 DIA----IMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPL 301
            |.|    ::..|:.::|.:||..| ....|.........|:....|.:..:||.|:.|..|.. :
  Fly   245 DYASALDVVHGFSSEIIAKRRDQL-NDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEKDGL-I 307

  Fly   302 SDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQT-KLLE 365
            ..:.|.||||..:|.|.|||:.|:...|..:|.:|:.||..|:|:.:.:  |.:.::... :|.:
  Fly   308 DHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANI--DDELNILNIGQLNK 370

  Fly   366 LKYLDCVIKETMRLHPPVPILGRYIPEDLKIGE-ITIPGNTSILLMPYYVYRDPEYFPDPLVFKP 429
            ||.|:..|||||||.|.||.:||....:.::.. :.:|..:.|.:..:.::|:|||:..|..|:|
  Fly   371 LKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRP 435

  Fly   430 ERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFIL 494
            ||::. :.:.|....||||||:|.:||||||||..:||.|:..:::.:::|| ..|.| |..|
  Fly   436 ERFLP-ENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILP-EIDPK-TIVF-- 495

  Fly   495 SSSTGNNVGLKPRTRVK 511
              .||..:..|.:..||
  Fly   496 --QTGLTLRTKNQIHVK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	142/472 (30%)
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	143/470 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460527
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17838at50557
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000