DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4p2

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	149/548 - (27%)
Similarity:	251/548 - (45%)	Gaps:	77/548 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWILLGIAVLIMTLVWDNSRKQWRVNTFEKSRI----------LGPF---------TIPIVGNGL 46
            :||.:.|.|:|..:...|  |.:.:..|...|:          |.|.         ...::|...
  Fly     6 LWISVAILVVIHWIYKVN--KDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDT 68

  Fly    47 QALTLRPENFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDF 111
            ..:........:..||.:.:|.       :|.......|.....:||:...|:.|..:|.||..|
  Fly    69 DQVFTHLRQLAKNSGDSYLQYS-------MGFSNFNVIDAHNAANILNHPNLITKGVIYNFLHPF 126

  Fly   112 LGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSL 176
            |..|:|.:|..||.:||.:|...||...|..|.||....|...|.:.:  ...:..|.|...:|.
  Fly   127 LRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQ--GQNEVVVSLKDRISR 189

  Fly   177 EALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPL-----VY- 235
            ..|:...|||||::::...|....|......:....::|:.:             ||     ||
  Fly   190 FTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVN-------------PLYWDDCVYN 241

  Fly   236 ----RRLQKDIAIMQDFTDKVIRERRAI----LERARADGTYKPLIMGDDDIG--GKAKMTLLDI 290
                .:....:.::.:|:.::|.:||.:    ||..||..|      .||||.  .|.:..:||.
  Fly   242 MFTGHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQT------ADDDICVIRKKRFAMLDT 300

  Fly   291 LLQATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVS-VLGPDP 354
            |:.|..|.. :.|:.|.||||..:..|.|||:.|:...|..:|.:...||..|:|:.. :|  |.
  Fly   301 LICAEKDGL-IDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHIL--DD 362

  Fly   355 DASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI-GEITIPGNTSILLMPYYVYRDP 418
            .:::..::|.:|.||...|||||||:|.:||:||...::.:: ..:.:|..:.|.:..:.::|:|
  Fly   363 LSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNP 427

  Fly   419 EYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLG 483
            :|:..|..|:|||::....... .|.||||||:|.:||||||:|..:||.|:..:::|:::||:
  Fly   428 KYWESPEEFRPERFLPQNCLKR-HPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPV- 490

  Fly   484 ADLKATYTFILSSSTGNNVGLKPRTRVK 511
            .|.|:     :....|..:..|.:.:||
  Fly   491 IDPKS-----IVFQVGITLRFKNKIKVK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	132/473 (28%)
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	138/489 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460529
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	7	6.990