Protein Alignment Cyp4d21 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 498
• Identity: 135/498 - (27%)
• Similarity: 246/498 - (49%)
• Gaps: 61/498 - (12%)

  Fly     3 ILLGIAVLIMTLVWDNSRKQWRVNT-----FEKSRILGPFTIPIVGNGLQALTLRPENFIQRFG- 61
            :||.|.::::          :|..|     |:|..|.||..:|.:|..|...|     .|.:|.
Mouse    13 VLLAIILVLL----------YRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYT-----GIWKFDM 62

  Fly    62 DYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDF-----LGDGLLLSTG 121
            :.:.|||||:.|:.....|:...|.:..:::|....|    .::...|:|     :...:.:|..
Mouse    63 ECYEKYGKTWGLFDGQTPLLVITDPETIKNVLVKDCL----SVFTNRREFGPVGIMSKAISISKD 123

  Fly   122 NKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETA 186
            .:|...|.:|:|.|....|:....::::...|:|:.|:..|:....|.:...:...::||.|.|:
Mouse   124 EEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMDVITSTS 188

  Fly   187 MGVQVNAQNEPNFPYTKALKSVVYIE--SKRLASVSMRYNWLFPLAAPLVYRRL------QKDIA 243
            .||.|::.|.|..|:.:..|..:.::  ...|.||.     ||||..| ||..|      ...|.
Mouse   189 FGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSVV-----LFPLLTP-VYEMLNICMFPNDSIE 247

  Fly   244 IMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIRE 308
            ..:.|.|::...|....::.|.|  :..|:|...: ..|.|.:           :|..|:::|..
Mouse   248 FFKKFVDRMQESRLDSNQKHRVD--FLQLMMNSHN-NSKDKDS-----------HKAFSNMEITV 298

  Fly   309 EVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVI 373
            :..:||.||.:||:|.:|..|:.::.||.:|:.:..|:...| |: .|:.|...::|::|||.|:
Mouse   299 QSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKAL-PN-KATPTCDTVMEMEYLDMVL 361

  Fly   374 KETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTT 438
            .||:||:|.|..|.|...:|:::..:.||..:.:::..|.::.||:::|||..|:|||: ..:..
Mouse   362 NETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERF-SKENK 425

  Fly   439 SNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481
            .:..|..|:||..||:||||.:||.:.||..::||::::...|
Mouse   426 GSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQP 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	117/427 (27%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	119/429 (28%)