DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4ac2

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	156/522 - (29%)
Similarity:	274/522 - (52%)	Gaps:	47/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IAVLIMTLVWDNSRKQW-------RVNTFE----KSRILGPFTIPIVGNGLQALTLRPENFIQRF 60
            :.:.|...:|.:..:.:       |:.|.:    :|:|....:....||....:....|:.....
  Fly    11 LVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTSESIFNFM 75

  Fly    61 GDYFNK-YGKTFRLWILGECLIYT-KDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNK 123
            .|...| .|:.: ||......:|. ...:..|.||.||.|:.|..:|..|:.|||:|||:||..|
  Fly    76 RDASAKAKGRNY-LWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQK 139

  Fly   124 WTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMG 188
            |.||||.|.||||||.|::|:.|.......:|:.|....:.:  ::|.:.:....|:...|||:|
  Fly   140 WHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNME--LELNQVIPQFTLNNVCETALG 202

  Fly   189 VQVNAQNEPNFPYTKALKSVVYIESKRLAS---VSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTD 250
            |:::..:| ...|.:::.::..:..:||.:   .::.|.:||.     .||:...::.|..:|:.
  Fly   203 VKLDDLSE-GIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFG-----DYRKQVNNLKIAHEFSS 261

  Fly   251 KVIRERRAILERARADGTYKPLIMG-DDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFI 314
            .:|.:||::         :|...:| :|:.|.|.:..:||.||.|..|.: :....|.:||:.|:
  Fly   262 NIIEKRRSL---------FKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQ-IDHQGICDEVNTFM 316

  Fly   315 FAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRL 379
            |.|.|||::.:...|..::.|..||:..|||:..:  ||....::..:..||.|::|||||::||
  Fly   317 FEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYL--PDDSDDISVFQFNELVYMECVIKESLRL 379

  Fly   380 HPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPL 444
            .|.||.:||...|:..:..:.:|.||.|.:..|.:.||..:|.:|.:|:|:|:.. :.|.|..|.
  Fly   380 FPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFP-ENTVNRHPF 443

  Fly   445 AYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFILSSSTGNNVGLKPRTR 509
            |::|||:|.:||||||||.|::|.|::.|||::::||:        |.:...:..|.:.|:.:..
  Fly   444 AFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPV--------TLLDDLTFENGIVLRTKQN 500

  Fly   510 VK 511
            :|
  Fly   501 IK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	145/452 (32%)
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	150/476 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460525
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.990