DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4ac1

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_608916.1	Gene:	Cyp4ac1 / 33754	FlyBaseID:	FBgn0031693	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	174/543 - (32%)
Similarity:	285/543 - (52%)	Gaps:	66/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWI-LLGIAVL--IMTLVWDNSRKQW-------RVNTFEKSRILGPFTI----PIVGNGLQALTL 51
            ||| ||||.:|  ::||:..:..|.:       ||.|.:.|.:.....|    ...||.|..|..
  Fly     1 MWIALLGIPILLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNF 65

  Fly    52 RPE---NFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYF--------------ESILSSSTLL 99
            .|.   ||::.  ......|:.: ||             ||              |.:..|:.|:
  Fly    66 TPASVFNFVRE--STAKAKGQNY-LW-------------YFLYAPMYNVVRPEEAEEVFQSTKLI 114

  Fly   100 KKAHLYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADG 164
            .|..:|..:|.|||||||:||.:||.||||.|.|||||..|::|:.|........:..|:...|.
  Fly   115 TKNVVYELIRPFLGDGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDA 179

  Fly   165 KTCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPL 229
            :  ::|.:.:....|:...|||:||:::..:|.| .|.||:.::..:..:|:.:..|.|||.|.:
  Fly   180 E--LELNQVIPPFTLNNICETALGVKLDDMSEGN-EYRKAIHAIEEVLIQRVCNPLMYYNWYFFV 241

  Fly   230 AAPLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGD-DDIGGKAKMTLLDILLQ 293
            ...  ||:..:::.|:.||:.::|..:|...::.:         :|: |:.|.|.:..:||.||.
  Fly   242 YGD--YRKHLQNLRIVHDFSSRIIERKRQQFQQKQ---------LGEVDEFGRKQRYAMLDTLLA 295

  Fly   294 ATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASV 358
            |..|.: :....|.:||:.|:|.|.|||::.:...|..::.|..||:..|||:.::  |:....:
  Fly   296 AEADGQ-IDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENL--PEDSDDI 357

  Fly   359 TQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPD 423
            :..:..:|.||:|||||::|:.|.||.:||...|:..:..:.:|.:|.|.:..|.:.|||.:||.
  Fly   358 SMFQFNKLVYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPK 422

  Fly   424 PLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKA 488
            |.:|:|:|::. :.|.|..|.||:|||:|.:||||||||.|:||.|::.|||:::|||.......
  Fly   423 PDLFQPDRFLP-ENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLEDL 486

  Fly   489 TYTFILSSSTGNNVGLKPRTRVK 511
            |:...:...|..|:.:|...|||
  Fly   487 TFENGIVLRTQENIKVKLSKRVK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	151/468 (32%)
Cyp4ac1	NP_608916.1	p450	86..504	CDD:278495	146/449 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460530
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.990