DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d21 and Cyp4g15

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	173/567 - (30%)
Similarity:	286/567 - (50%)	Gaps:	80/567 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLIMTLV-----WDNSRKQ-WRVNTFEKSRILGPFTIPIVGNGLQALTLRPENF--IQRFGDYFN 65
            :|:.|||     |..||.. :|:    ..|:.||..:||||:....:......|  :.|....|.
  Fly    20 LLLPTLVLWYIYWRLSRAHLYRL----AGRLPGPRGLPIVGHLFDVIGPASSVFRTVIRKSAPFE 80

  Fly    66 KYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTSRRKV 130
            ...|   :||..:.:::..|.:..|.:|||...:.||..|:|.:.:||||||:|||.||.|.||:
  Fly    81 HIAK---MWIGPKLVVFIYDPRDVELLLSSHVYIDKASEYKFFKPWLGDGLLISTGQKWRSHRKL 142

  Fly   131 LAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVNAQN 195
            :||.||...|::|:|:.:.||..:|.||: ..||:| .|...::|...:::..||||||....|:
  Fly   143 IAPTFHLNVLKSFIELFNENSRNVVRKLR-AEDGRT-FDCHDYMSEATVEILLETAMGVSKKTQD 205

  Fly   196 EPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERR--- 257
            :..|.|..|:..:..|...|..|:.:|..::|.|..  .|:...:.:.|:...|.||||.::
  Fly   206 KSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTR--YYKEQGRLLNIIHGLTTKVIRSKKAAF 268

  Fly   258 ---------------AILERAR-------------------------------------ADGTYK 270
                           |.|||.|                                     :.|...
  Fly   269 EQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEKASPVAGLSYGQSAGLKD 333

  Fly   271 PLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRH 335
            .|.:.|:|||.|.::..||::|::..:...::|.:|:|:||..:|.|.|||.:|.|..|..:..|
  Fly   334 DLDVEDNDIGEKKRLAFLDLMLESAQNGALITDTEIKEQVDTIMFEGHDTTAAGSSFFLSLMGIH 398

  Fly   336 PKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GE 398
            ..:|:.:..||.|:.| |.....|....||:|||:..:.||:|::||||::.|.:.||||:  |.
  Fly   399 QDIQDRVLAELDSIFG-DSQRPATFQDTLEMKYLERCLMETLRMYPPVPLIARELQEDLKLNSGN 462

  Fly   399 ITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFAN 463
            ..||...::.:....::|:|:.:.:|.||.|:.::. :..:|....|::|||:||::|:|:|:|.
  Fly   463 YVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLP-ERQANRHYYAFVPFSAGPRSCVGRKYAM 526

  Fly   464 LQMKALISKVIRHYELLP--LGADLKATYTFILSSSTGNNVGLKPRT 508
            |::|.|:|.::|:|.:..  ..:|.|.....||....|..|.|:|||
  Fly   527 LKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQPRT 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	154/507 (30%)
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	154/503 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	6	5.960