DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	162/543 - (29%)
Similarity:	286/543 - (52%)	Gaps:	52/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLGIAVLIMTLV-----------WDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFI 57
            :||.:.::.|||           |..:.:::|:    .:.|..|..:||:|....|..|.....:
  Fly    21 VLGFSPMLTTLVGTLVAMALYEYWRRNSREYRM----VANIPSPPELPILGQAHVAAGLSNAEIL 81

  Fly    58 QRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGN 122
            .....|.||||:|.:.|:....|::..:....|.|||....|.||..||:.:.:.|||||:|.|:
  Fly    82 AVGLGYLNKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGH 146

  Fly   123 KWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAM 187
            .|...||::||.||...|::||.....:|..:|.::...| ||: .|:..::|...:|:...|||
  Fly   147 HWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEA-GKS-FDVHDYMSQTTVDILLSTAM 209

  Fly   188 GVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKD----IAIMQDF 248
            ||:...:...:|.|.:|:..:..|..||...:..|.:.::.      :.:|::.    :.|:...
  Fly   210 GVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYK------FTKLREKGDRMMNIILGM 268

  Fly   249 TDKVIRER--------RAILER----------ARADGTYKPL-IMGDDDIGGKAKMTLLDILLQ- 293
            |.||:::|        |||:|.          ::.:|....| .:.::|:|.|.::.|||.:::
  Fly   269 TSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEM 333

  Fly   294 ATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASV 358
            |...:...::.||.:||:..:|.|.|||::|.|.||..:..|..:|..::.|..::.|.:.....
  Fly   334 AKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDC 398

  Fly   359 TQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPEYF 421
            |....:|:|||:.||.||:||:||||::.|.:..|||:  |..|:|..|:::::.|.|:|.|:.:
  Fly   399 TFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIY 463

  Fly   422 PDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHY--ELLPLGA 484
            |:|..|.|:.::. :..:|....::||||:||::|:|:|:|.|::|.|:|.::|:|  ......|
  Fly   464 PNPTKFDPDNFLP-ERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEA 527

  Fly   485 DLKATYTFILSSSTGNNVGLKPR 507
            |.|.....||....|.||.|:.|
  Fly   528 DFKLQADIILKLENGFNVSLEKR 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	144/474 (30%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	143/468 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	7	7.060