DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	137/456 - (30%)
Similarity:	223/456 - (48%)	Gaps:	69/456 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 RLWILGECLIYTKDLK---------------------------------YFESILSSSTLL--KK 101
            |.|:||...:|..:.|                                 |.:.:|.:|..:  |.
  Rat    65 RHWLLGHMSMYLPNEKGLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKD 129

  Fly   102 AHLYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNY-ADGK 165
            ...|.||:.:||||||:|.||||:..|::|.|||||..|:.:::|.:::..||..|.:.: |:|.
  Rat   130 EFFYSFLKPWLGDGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQSVNIMHAKWRRHLAEGS 194

  Fly   166 -TCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPL 229
             |..|:|:.|||..||...:.......:.|.:    .:..:.|::     .|:::.:|..:....
  Rat   195 VTSFDMFEHVSLMTLDSLQKCVFSYSSDCQEK----LSDYISSII-----ELSALVVRRQYRLHH 250

  Fly   230 AAPLVY------RRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTL- 287
            ....:|      ||.::....:.:||.:||::||..|....|:...|          .|...||
  Rat   251 YLDFIYYLTADGRRFRQACDTVHNFTTEVIQQRRRALRELGAEAWLK----------AKQGKTLD 305

  Fly   288 -LDILLQA-TIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVL 350
             :|:||.| ..:.|.|||.|||.|.|.|:|.|.|||:||:|.||..::::|:.|:...||:..|:
  Rat   306 FIDVLLLAKDEEGKELSDEDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVM 370

  Fly   351 GPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYY 413
            .......:....|.:|.:....|||::|..|||.::.|...||:|:  |.| ||.....|:..|.
  Rat   371 KGRELEELDWDDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGRI-IPKGIICLVSIYG 434

  Fly   414 VYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYE 478
            .:.:|..:||..|:.|.|: |........|||::|||:||:|||||.||..:|:.:::..:..:.
  Rat   435 THYNPLVWPDSKVYNPYRF-DPDIPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFR 498

  Fly   479 L 479
            |
  Rat   499 L 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	137/456 (30%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	131/439 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750