DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	168/540 - (31%)
Similarity:	256/540 - (47%)	Gaps:	75/540 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WILL---GIAVL---IMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRF 60
            |:||   |.:.|   |:..|:         ..||.||.|..|..|...|.|             |
  Rat    19 WLLLLLVGASCLLAYILPQVY---------AVFENSRRLRRFPQPPTRNWL-------------F 61

  Fly    61 GD------------YFNKYGKTFR---LWILGECLIYTKDLKYFESILSSSTLLKKAHL------ 104
            |.            |.....:|||   .|.:|.   :...::.|........:|..|.:
  Rat    62 GHLGLIQSSEEGLLYIQSLSRTFRDVCCWWVGP---WHPVIRIFHPAFIKPVILAPASVAPKDRV 123

  Fly   105 -YRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYA-DGKTC 167
             ||||:.:||||||||||:||:..|.:|.|||||..|:.:|:|.:.::.||..|.:..| .|...
  Rat   124 FYRFLKPWLGDGLLLSTGDKWSRHRHMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLASQGSAR 188

  Fly   168 VDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAP 232
            :|:|:.:||..||...:.......|.|.:|: .|..|:..:..:.::|..|:.:..:..:.|...
  Rat   189 LDMFEHISLMTLDSLQKCVFSFDSNCQEKPS-EYITAILELSALVARRHQSLLLYVDLFYHLTRD 252

  Fly   233 LVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----ILLQ 293
            .:  |.:|...::.||||.||||||..|          |...|||.:..|||...||    :||.
  Rat   253 GM--RFRKACRLVHDFTDAVIRERRRTL----------PDQGGDDALKAKAKAKTLDFIDVLLLS 305

  Fly   294 ATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASV 358
            .....:.|||.|||.|.|.|:|.|.|||.||:|..|:.:::||:.||...:|:..:|.......:
  Rat   306 KDEHGEALSDEDIRAEADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEI 370

  Fly   359 TQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPEYF 421
            ....|.:|.:|...|||::|||||...:.|...:|:.:  |.: ||......:..:..:.:|..:
  Rat   371 EWDDLAQLPFLTMCIKESLRLHPPATAISRCCTQDIMLPDGRV-IPKGVICRISIFGTHHNPAVW 434

  Fly   422 PDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADL 486
            |||.|:.|.|: |........|||:||||:||:|||||.||..:||..::..:..:.:||...:.
  Rat   435 PDPEVYNPFRF-DADNGEGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEP 498

  Fly   487 KATYTFILSSSTGNNVGLKP 506
            :.....||.:..|..:.::|
  Rat   499 RRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	151/475 (32%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	149/458 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750