DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4f4

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_775146.1	Gene:	Cyp4f4 / 286904	RGDID:	708363	Length:	522	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	156/453 - (34%)
Similarity:	242/453 - (53%)	Gaps:	31/453 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 YGKTFRLWILGECL-IYT---KDLKYFESIL--SSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWT 125
            |.:.|..| ||..| |.|   .|:  ..|:|  |:|..||:...|.||:.:||||||||.|:||:
  Rat    84 YPQGFMTW-LGPILPIITLCHPDV--IRSVLSASASVALKEVIFYSFLKPWLGDGLLLSDGDKWS 145

  Fly   126 SRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTC-VDLFKFVSLEALDVTTETAMGV 189
            ..|::|.|||||..|:.:|:|.:.::.||..|.::.|.|.:. :|:||.:||..||...:.....
  Rat   146 CHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLASGGSARLDMFKNISLMTLDSLQKCVFSF 210

  Fly   190 QVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIR 254
            ..|.|.:|: .|..|:..:..:.:||...:.:..:.|:.|...  .||..|...::.:|||.||:
  Rat   211 DSNCQEKPS-EYISAILELSALVAKRYQQLLLHTDSLYQLTHN--GRRFHKACKLVHNFTDAVIQ 272

  Fly   255 ERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----ILLQATIDNKPLSDVDIREEVDVFIF 315
            .||..|          |....||.:..||:...||    :||....|.|.|||.|||.|.|.|:|
  Rat   273 GRRRAL----------PSQHEDDILKAKARSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMF 327

  Fly   316 AGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLH 380
            .|.|||.||:|..|:.::|||:.||...:|:..:|.......:....|.:|.:|...|||::|||
  Rat   328 EGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKESLRLH 392

  Fly   381 PPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPP 443
            |||.::.|...:|:.:  |.: ||.....::..:..:.:|..:|||.|:.|.|: |.:...:..|
  Rat   393 PPVTVISRRCTQDIVLPDGRV-IPKGVICIINIFATHHNPTVWPDPEVYDPFRF-DPENIKDRSP 455

  Fly   444 LAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFILSSSTGNNVGLKP 506
            ||:||||:||:|||||.||..:||..::..:..:.:||...:.:.....||.:..|..:.::|
  Rat   456 LAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	151/427 (35%)
Cyp4f4	NP_775146.1	CYP4F	74..515	CDD:410772	155/448 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750