Protein Alignment Cyp4d21 and Cyp4a12a

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_803125.2
• Gene: Cyp4a12a / 277753
• MGIID: 88612
• Length: 508
• Species: Mus musculus
• Alignment Length: 528
• Identity: 142/528 - (26%)
• Similarity: 257/528 - (48%)
• Gaps: 72/528 - (13%)

  Fly     4 LLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIP----------IVGNGLQALTLRPENFIQ 58
            :|.:.:|:.........:||.:::.::      |..|          :....||.:..|.:||..
Mouse    24 VLSLLLLLFKTAQLYLHRQWLLSSTQQ------FPSPPSHWLFGHKILKDQDLQDILTRIKNFPS 82

  Fly    59 RFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAH-LYRFLRDFLGDGLLLSTGN 122
            ....:.  :|...|:      .:|..|  |.:.||..|.  .||: .||||..::|.|||:..|.
Mouse    83 ACPQWL--WGSKVRI------QVYDPD--YMKLILGRSD--PKANGSYRFLAPWIGRGLLMLDGQ 135

  Fly   123 KWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAM 187
            .|...|::|.||||:..|:.:.|||..:..:|::|.:......:.:::|:.::|..||...:.|.
Mouse   136 TWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAF 200

  Fly   188 GVQVNAQNEPNF-PYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYR------RLQKDIAIM 245
            ..:.:.|.:..: .|.:|::.:..:...|:.::..:.:        ::||      :......:.
Mouse   201 SHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNIFHQND--------IIYRVSSNGCKANSACKLA 257

  Fly   246 QDFTDKVIRERRAILERARADGTYKPLIMGDDD----IGGKAKMTLLDILLQATIDN-KPLSDVD 305
            .|.||:||:.||..|:              |::    :..|.::..|||||.|.::| |.|||.|
Mouse   258 HDHTDQVIKSRRIQLQ--------------DEEELEKLKKKRRLDFLDILLFARMENGKSLSDKD 308

  Fly   306 IREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLD 370
            :|.|||.|:|.|.|||.||:|...:|::.:|:.|:...:|:.|:||  ...|:|...|.::.|..
Mouse   309 LRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLG--DGTSITWNDLDKMPYTT 371

  Fly   371 CVIKETMRLHPPVPILGRYI--PEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWM 433
            ..|||.:|::||||.:.|.:  |.....|. ::|....::|..|.::.:|..:|:|.||.|.|:
Mouse   372 MCIKEALRIYPPVPSVSRELSSPVTFPDGR-SLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRF- 434

  Fly   434 DMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATY-TFILSSS 497
              ...|:....:::|||.|.:||||::||..::|..::..:..:||||....:.... ..:|.|.
Mouse   435 --APGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSK 497

  Fly   498 TGNNVGLK 505
            .|.::.||
Mouse   498 NGIHLHLK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	129/449 (29%)
Cyp4a12a	NP_803125.2	CYP4B-like	70..503	CDD:410771	134/472 (28%)