DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d21 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	186/556 - (33%)
Similarity:	291/556 - (52%)	Gaps:	86/556 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWILLGIAVLIMTLVWDNSRK-------------QWRVNTFEKSRILGPF-----TIPIVGNGLQ 47
            :|:.||::...: |:|..:..             |..|:...|.:.:.|.     ..|:||:
  Rat     2 LWLWLGLSGQKL-LLWGAASAVSVAGATVLLNILQMLVSYARKWQQMRPIPSVARAYPLVGH--- 62

  Fly    48 ALTLRPEN--FIQRFGDYFNKYG--KTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFL 108
            ||.::|.|  |.|:...|..::.  ...:|||....|:.....:..|.||:||..:.|:.:|:||
  Rat    63 ALFMKPNNTEFFQQIIQYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFMYKFL 127

  Fly   109 RDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKF 173
            :.:||.|||.|||:||.:|||:|.|:|||..||:|:::|:..:.|:|.||:.:.: :...:.|..
  Rat   128 QPWLGLGLLTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVN-QEAFNCFFP 191

  Fly   174 VSLEALDVTTETAMGVQVNAQNEPNFPYTKA---LKSVVYIESKRLASVSMRYNWLFPLAAPLVY 235
            ::|.|||:..|||||..:.||:..:..|.:.   :..::|...|      |.:.|.     .|.|
  Rat   192 ITLCALDIICETAMGKNIGAQSNGDSEYVRTVYRMSDMIYRRMK------MPWFWF-----DLWY 245

  Fly   236 ------RRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIG-GKA-------KMT 286
                  |..:|.:..:..||:.||.||   :...:|:         .|.|| |:.       :..
  Rat   246 LMFKEGRDHKKGLKSLHTFTNNVIAER---VNARKAE---------QDCIGAGRGPLPSKTKRKA 298

  Fly   287 LLDILLQATID--NKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSV 349
            .||:||..|.:  || ||..|||||||.|:|.|.|||.:.::.:|:.:..:|:||..:.:||..|
  Rat   299 FLDLLLSVTDEEGNK-LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDV 362

  Fly   350 LGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYV 414
            .|.. ...||...|.:|||||||||||:|:.|.||:..|.:.||.::....|...|..:::||.:
  Rat   363 FGRS-HRPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVAGYKISKGTEAVIIPYAL 426

  Fly   415 YRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHY-- 477
            :|||.|||||..|:|||:.. :.:....|.||:|||:||:||||||||.::.|.:::.::|.:
  Rat   427 HRDPRYFPDPEEFQPERFFP-ENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWI 490

  Fly   478 ------ELLPLGADLKATYTFILSSSTGNNVGLKPR 507
                  |.|.|..||      ||..:.|..:.||.|
  Rat   491 ESNQKREELGLAGDL------ILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	169/482 (35%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	165/471 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.840