DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	424	Identity:	144/424 - (33%)
Similarity:	230/424 - (54%)	Gaps:	22/424 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKL 158
            |::...|:..||.||:.:||||||:|.|.||...|::|.|||||..|:::|:|.:::...|..|.
  Rat   115 SAAVAPKEMTLYGFLKPWLGDGLLMSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKW 179

  Fly   159 KNY-ADGKTCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMR 222
            :.. |.|...:|:|:.:||..||...:.......|.| |.|..|..|:..:..:..||.....:.
  Rat   180 QRLTAKGSARLDMFEHISLMTLDSLQKCIFSFDSNCQ-ESNSEYIAAILELSSLIVKRQRQPFLY 243

  Fly   223 YNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAK--- 284
            .::|:.|.|.  .||.:|...::.:|||.||||||:.|.....|...|          .:||
  Rat   244 LDFLYYLTAD--GRRFRKACDVVHNFTDAVIRERRSTLNTQGVDEFLK----------ARAKTKT 296

  Fly   285 MTLLDILLQATIDN-KPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVS 348
            :..:|:||.|..:: |.|||||||.|.|.|:|.|.|||.|.:|..|:.::|||:.||...:|:..
  Rat   297 LDFIDVLLLAKDEHGKGLSDVDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVRE 361

  Fly   349 VLGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMP 411
            :|.......:....|.:|.:|...|||::||||||.::.|...:|:.:  |.:...||..::.:
  Rat   362 LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCSQDIVLPDGRVIPKGNICVISI- 425

  Fly   412 YYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRH 476
            :.|:.:|..:|||.|:.|.|: |.:......|||:||||:||:|||||.||..::|..::..:..
  Rat   426 FGVHHNPSVWPDPEVYNPFRF-DPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLR 489

  Fly   477 YELLPLGADLKATYTFILSSSTGNNVGLKPRTRV 510
            :.:||...:.:.....||.:..|..:.::|.:.|
  Rat   490 FCVLPDDKEPRRKPELILRAEGGLWLRVEPLSTV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	138/394 (35%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	142/414 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740