DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	437	Identity:	133/437 - (30%)
Similarity:	231/437 - (52%)	Gaps:	37/437 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QRFGDYFNKYGKTF----RLWILGECL-IYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLL 117
            |.|.|...:. |.|    ..|:.|..: |...|..|.:.||..|. .|..|.||||..::|.|||
  Rat    70 QEFQDILTRV-KNFPSACPQWLWGSNVRIQVYDPDYMKLILGRSD-PKSHHSYRFLAPWIGYGLL 132

  Fly   118 LSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVT 182
            |..|..|...|::|.||||:..|:.:|.||..:..||::|.:......:.:::|:.::|..||..
  Rat   133 LLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTI 197

  Fly   183 TETAMGVQVNAQNEPNF-PYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQ 246
            .:.|...:.:.|.:..: .|.||::.:..:...|:.::..:.:.::.|::.  .|:.:....:..
  Rat   198 MKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSN--GRKARSAWQLAH 260

  Fly   247 DFTDKVIRERRAILERARADGTYKPLIMGDDD----IGGKAKMTLLDILLQATIDN-KPLSDVDI 306
            :.||:||:.|:|.|:              |::    :..|.::..|||||.|.|:| ..|||.|:
  Rat   261 EHTDQVIKSRKAQLQ--------------DEEELQKVKQKRRLDFLDILLFARIENGSSLSDKDL 311

  Fly   307 REEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDC 371
            |.|||.|:|.|.|||.||:|...:|::.:|:.|:...:|:.|:||  ..||:|...|.::.|...
  Rat   312 RAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLG--DGASITWDDLDKMPYTTM 374

  Fly   372 VIKETMRLHPPVPILGRYI--PEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMD 434
            .|||.:|::|||..:.|.:  |.....|. ::|...:::|..|.::.:|..:|:|.||.|.|:
  Rat   375 CIKEALRIYPPVTAVSRMLSTPVTFPDGR-SLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRF-- 436

  Fly   435 MKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481
             ...|:....:::|||.|.:||||::||..::|..::..:..:||||
  Rat   437 -APESSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	133/437 (30%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	132/435 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750