Protein Alignment Cyp4d21 and CYP4X1

DIOPT Version :9

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 150/495 - (30%)
• Similarity: 249/495 - (50%)
• Gaps: 58/495 - (11%)

  Fly    32 RILGPFTIP----IVGNGLQALTLRPENFIQ-----RFGDYFNKYGKTFRLWILGE-----CLIY 82
            |.|.||..|    .:|:         :.|||     :..:...||.:.|..|| |.     | ||
Human    41 RDLRPFPAPPTHWFLGH---------QKFIQDDNMEKLEEIIEKYPRAFPFWI-GPFQAFFC-IY 94

  Fly    83 TKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIM 147
            ..|  |.:::| |.|..|..:|.:|....||.||....|.||...|::|.|.|||..|:.::|:|
Human    95 DPD--YAKTLL-SRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVM 156

  Fly   148 DRNSGIMVEKLKNYADGK-TCVDLFKFVSLEALDVTTETAMGVQVNAQ-NEPNFPYTKALKSVVY 210
            ..:..:|::|.:.....: |.|::::.::..:||:..:.|...:.|.| |..:.||.||:..:..
Human   157 AHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSK 221

  Fly   211 IESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERRAILER-ARADGTYKPLIM 274
            |...||.|:....:.:|.| :|..| |.||...::..:||.:|:||:..|:. .:.|.|.|
Human   222 IIFHRLYSLLYHSDIIFKL-SPQGY-RFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPK---- 280

  Fly   275 GDDDIGGKAKMTLLDILLQATIDN-KPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKV 338
                   :.....|||:|.|..:: ...||:|:..||..|:.||.||..:.:|..|:.::.:|:.
Human   281 -------RKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEH 338

  Fly   339 QECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGE-ITIP 402
            ||...||:..:||  ..:|:|..:|.|:.|....||||.||.|.||.:.|.:.:.|...: .|:|
Human   339 QERCREEVRGILG--DGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLP 401

  Fly   403 GNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMK 467
            ...:::|..:.::.:|..:.:|.||.|.|: ..:.:....|.||:|||:|.:|||||:||.:::|
Human   402 AGITVVLSIWGLHHNPAVWKNPKVFDPLRF-SQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELK 465

  Fly   468 ALISKVIRHYELLPLGADLKATYTFILSSSTGNNVGLKPR 507
            ..|:.::.|:.:.|   |.....||      .|:..|||:
Human   466 VTIALILLHFRVTP---DPTRPLTF------PNHFILKPK 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	140/465 (30%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	146/489 (30%)
		heme binding region	447..460		8/12 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154708
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840