Protein Alignment Cyp4d21 and Cyp3a23-3a1

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 140/506 - (27%)
• Similarity: 248/506 - (49%)
• Gaps: 77/506 - (15%)

  Fly     2 WILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENF---IQRFG-D 62
            |:||  ||:::.|....:|..   ..|:|..|.||..:|..|..|        |:   :.:|. :
  Rat    12 WVLL--AVVLVLLYGFGTRTH---GLFKKQGIPGPKPLPFFGTVL--------NYYMGLWKFDVE 63

  Fly    63 YFNKYGKTFRLWIL--GECLIYT-KDLKYFESILSSSTLLKKAHLYRFLRDF-----LGDGLLLS 119
            ...||||   :|.|  |:..::. .|.:..:::|.....    .::...|||     :|..:.:|
  Rat    64 CHKKYGK---IWGLFDGQMPLFAITDTEMIKNVLVKECF----SVFTNRRDFGPVGIMGKAISVS 121

  Fly   120 TGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTE 184
            ...:|...|.:|:|.|....|:....::::...|:|:.|:. ..||. |.:.:.....::||.|.
  Rat   122 KDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQ-EKGKP-VPVKEVFGAYSMDVITS 184

  Fly   185 TAMGVQVNAQNEPNFPYTKALKSVVYIE--SKRLASVSMRYNWLFPLAAPLVYRRLQ-----KD- 241
            |:.||.|::.|.|..|:.:..|.::.|:  .....||.     |||...| ||..|.     ||
  Rat   185 TSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVV-----LFPFLTP-VYEMLNICMFPKDS 243

  Fly   242 IAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNK------P 300
            |...:.|..::...|...:::.|.|                    .|.:::.|..|:|      .
  Rat   244 IEFFKKFVYRMKETRLDSVQKHRVD--------------------FLQLMMNAHNDSKDKESHTA 288

  Fly   301 LSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLE 365
            |||::|..:..:|||||.:.|:|.:|..||:::.||..|:.:.||:...| |: .|..|...::|
  Rat   289 LSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRAL-PN-KAPPTYDTVME 351

  Fly   366 LKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPE 430
            ::|||.|:.||:||:|....|.|...:|::|..:.:|..:.:::..|.::|||:::|:|..|:||
  Rat   352 MEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPE 416

  Fly   431 RWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481
            |: ..:...:..|..|:||.:||:||||.:||.:.||..::||::::...|
  Rat   417 RF-SKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQP 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	121/436 (28%)
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	123/438 (28%)