DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d21 and erg11

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_592990.1	Gene:	erg11 / 2542599	PomBaseID:	SPAC13A11.02c	Length:	495	Species:	Schizosaccharomyces pombe

Alignment Length:	536	Identity:	122/536 - (22%)
Similarity:	213/536 - (39%)	Gaps:	97/536 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILLGIAV------LIMTLVWDNSRK-----QWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENF 56
            |||.||:      :|..|...||::     .|               ||.||:.: |..:.|..|
pombe     8 ILLSIALAWYVGYIINQLTSRNSKRPPIVFHW---------------IPFVGSAV-AYGMDPYVF 56

  Fly    57 IQRFGDYFNKYGKTFRLWILGECL-----IYTKDLKYFESILSSSTLLKKAHLYR--FLRDFLGD 114
               |.:...|||..|....:|..:     :...|..:...:...:.....:||..  |.:|.:.|
pombe    57 ---FRECRAKYGDVFTFVCMGRKMTAFLGVQGNDFLFNGKLADLNAEEAYSHLTTPVFGKDVVYD 118

  Fly   115 GLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCV-DLFKFVSLEA 178
                ...:.:...:|.:.....|....::|.::.......:....::..||..| ||.|.:.:..
pombe   119 ----IPNHVFMEHKKFIKSGLGFSQFRSYVPLILNEMDAFLSTSPDFGPGKEGVADLLKTMPVMT 179

  Fly   179 LDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIA 243
            :...:.|..|.:|....:..|      ..:.:...:..:.|:..:.|| ||.     |..::|.|
pombe   180 IYTASRTLQGAEVRKGFDAGF------ADLYHDLDQGFSPVNFVFPWL-PLP-----RNRRRDRA 232

  Fly   244 --IMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDI 306
              |||....|:|::||:..|....|..:                ||:....:   |.:||.:.:|
pombe   233 HKIMQKTYLKIIKDRRSSTENPGTDMIW----------------TLMSCKYR---DGRPLKEHEI 278

  Fly   307 REEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDC 371
            ...:...:.||..|:.:.:...|..:...|::.|.::||...|:|.:.:....|.|  ::..|:.
pombe   279 AGMMIALLMAGQHTSAATIVWVLALLGSKPEIIEMLWEEQKRVVGENLELKFDQYK--DMPLLNY 341

  Fly   372 VIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMD 434
            ||:||:|||||:....|.:..||.:  .:|.||.|..:|..|.....:.|||.....|.|:||.|
pombe   342 VIQETLRLHPPIHSHMRKVKRDLPVPGSKIVIPANNYLLAAPGLTATEEEYFTHATDFDPKRWND 406

  Fly   435 ----------------MKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLG 483
                            :.|.....|  |:||.:|...|||::||.:.:..:|||.:..|....:|
pombe   407 RVNEDENAEQIDYGYGLVTKGAASP--YLPFGAGRHRCIGEQFAYMHLSTIISKFVHDYTWTLIG 469

  Fly   484 ADLKATYTFILSSSTG 499
            ......|:.:::...|
pombe   470 KVPNVDYSSMVALPLG 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	109/474 (23%)
erg11	NP_592990.1	CypX	28..495	CDD:225035	115/516 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto100901
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R248
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.990