Protein Alignment Cyp4d21 and Cyp11b2

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_036670.2
• Gene: Cyp11b2 / 24294
• RGDID: 2454
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 551
• Identity: 121/551 - (21%)
• Similarity: 226/551 - (41%)
• Gaps: 100/551 - (18%)

  Fly     5 LGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRP---------------- 53
            :.:|:.:...||  ..:.|:  ...::|.||....      |...||:|
  Rat     1 MAMALRVTADVW--LARPWQ--CLHRTRALGTTAT------LAPKTLKPFEAIPQYSRNKWLKMI 55

  Fly    54 --------ENFIQRFGDYFNKYGKTFRLWILGECLIY------TKDLKYFESILSSSTLLKKAHL 104
                    ||........|.:.|..||....|..::.      .:.|...||||.....|:....
  Rat    56 QILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMHLEPWVA 120

  Fly   105 YRFLRDFLGDGLLLSTGNKWTSRR-----KVLAPAFHFKCLENFVEIMDRNSGIMVE----KLKN 160
            :|.||. |..|:.|..|..|...|     .||:|    |.::|||.::|..:...:|    |::.
  Rat   121 HRELRG-LRRGVFLLNGADWRFNRLKLNPNVLSP----KAVQNFVPMVDEVARDFLEALKKKVRQ 180

  Fly   161 YADGKTCVD----LFKFVSLEALDVTT-ETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVS 220
            .|.|...:|    ||.: ::||.:... ...:|:..:..|..:..:..||.|:....::.|....
  Rat   181 NARGSLTMDVQQSLFNY-TIEASNFALFGERLGLLGHDLNPGSLKFIHALHSMFKSTTQLLFLPR 244

  Fly   221 MRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKM 285
            ....|    .:..|::.......::.::.::.|.:....| |..:..||..::..
  Rat   245 SLTRW----TSTRVWKEHFDAWDVISEYANRCIWKVHQEL-RLGSSQTYSGIVAA---------- 294

  Fly   286 TLLDILLQATIDNKPLSDVDIREEVDVFIFAGD-DTTTSGVSHALHAISRHPKVQECIYEELVSV 349
                ::.|..:   ||   |..:...:.:.||. |||...:...|..::|:|.||:.:.:|.::.
  Rat   295 ----LITQGAL---PL---DAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAA 349

  Fly   350 LGPDPDASVT---QTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMP 411
                 :||:.   |..:.:|..|...:|||:||:|....|.|.:..||.:....:|..|.:||..
  Rat   350 -----EASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYL 409

  Fly   412 YYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRH 476
            |.:.|:|..||.|..:.|:||::.|.:     ..::.|..|.:.|:|::.|.::|..|:..:::.
  Rat   410 YSMGRNPAVFPRPERYMPQRWLERKRS-----FQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKT 469

  Fly   477 YELLPL-GADLKATYTFILSSSTGNNVGLKP 506
            :::..| ..|::..|.|:|..|:...:..:|
  Rat   470 FQVETLRQEDVQMAYRFVLMPSSSPVLTFRP 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	106/458 (23%)
Cyp11b2	NP_036670.2	cytochrome_P450	74..498	CDD:477761	107/464 (23%)