DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001094915.1	Gene:	Cyp4f17 / 208285	MGIID:	3646233	Length:	524	Species:	Mus musculus

Alignment Length:	475	Identity:	155/475 - (32%)
Similarity:	244/475 - (51%)	Gaps:	36/475 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GLQALTLRPENFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLL--KKAHLYRF 107
            |||.||.|...|......:...:....|       ||:.   |:...||.:|..:  |:...|.|
Mouse    73 GLQLLTERSHQFHDVHLCWIGPFYPILR-------LIHP---KFIGPILQASAAVAPKEMIFYGF 127

  Fly   108 LRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNY-ADGKTCVDLF 171
            |:.:||||||:|.|.||:..|.:|.|||||..|:.:::..:::..||..|.:.. ..|..|:|:.
Mouse   128 LKPWLGDGLLVSAGEKWSRHRHLLTPAFHFDILKPYMKNFNKSVNIMHAKWQRLTTKGTACLDML 192

  Fly   172 KFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYR 236
            :.:||..||...........|.|..|: .|..|::.:..:..||.....:..::|:...|.  .|
Mouse   193 EHISLMTLDSLQNCVFSFDSNCQESPS-EYIAAIQELSSLIVKRHHQPFLYLDFLYYCTAD--GR 254

  Fly   237 RLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAK---MTLLDILLQATIDN 298
            |.:|...::.:|||.||||||..|.....|...|          .|.|   :..:|:||.|..::
Mouse   255 RFRKACDLVHNFTDAVIRERRRTLSSQNLDEFLK----------SKTKSKTLDFIDVLLLAKDEH 309

  Fly   299 -KPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVL-GPDPDASVTQT 361
             |.|||.|||.|.|.|:|.|.|||.|.:|..|:.::|||:.||...:|:..:| |.:|. .:...
Mouse   310 GKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQ-EIEWD 373

  Fly   362 KLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPEYFPDP 424
            .|.:|.:|...|||::||||||.::.|...:|:.:  |.: ||..|..::..:.|:.:||.:|||
Mouse   374 DLAQLPFLTMCIKESLRLHPPVTVISRCCTQDVVLPDGRV-IPKGTDCVISIFGVHHNPEVWPDP 437

  Fly   425 LVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKAT 489
            .|:.|.|: |.:......|||:||||:||:|||||.||..:||..::..:..:.:||...:.:..
Mouse   438 EVYDPFRF-DPENPQKRSPLAFIPFSAGPRNCIGQTFAMREMKVALALTLLRFRVLPGDKEPRRK 501

  Fly   490 YTFILSSSTGNNVGLKPRTR 509
            ...||.:..|..:.::|.::
Mouse   502 PELILRAEGGLWLRVEPLSK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	150/446 (34%)
Cyp4f17	NP_001094915.1	p450	52..515	CDD:365848	154/467 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845174
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740