Protein Alignment Cyp4d21 and cyp-13A2

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_496109.1
• Gene: cyp-13A2 / 188360
• WormBaseID: WBGene00011676
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 556
• Identity: 128/556 - (23%)
• Similarity: 224/556 - (40%)
• Gaps: 106/556 - (19%)

  Fly     3 ILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFGDYFNKY 67
            |.|||....:          |....:.:..:.||...|.|| .|..|.......:.:.|::..||
 Worm    13 IFLGILTYYL----------WIWTYWMRKGVKGPRGRPFVG-VLDVLLEHETPGLIKLGEWTKKY 66

  Fly    68 GKTF--------RLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGD-------GLL 117
            ||.:        .|.:....:::...:|.|::...           |.|....|:       .||
 Worm    67 GKVYGYTDGTQRTLVVADPAMVHEIFVKQFDNFYG-----------RKLNPIQGNPEKEQRVHLL 120

  Fly   118 LSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVT 182
            .:.|.:|...|.:.:.:|....|:.....::.::..::..::....|...:|:.:|.....:||.
 Worm   121 AAQGYRWKRLRTISSQSFSNASLKKMKRTVEDSALELLRHIEKQTAGGEQIDMLRFYQEYTMDVI 185

  Fly   183 TETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLV------YRRLQ-- 239
            ...||| |.::....| |....::.:.....|.|..:..    :||.....:      :.|:.
 Worm   186 GRFAMG-QTDSMMFKN-PIVNVVREIFCGSRKNLMLICQ----VFPPIGQFIRDLTFKFPRIPAF 244

  Fly   240 KDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDN------ 298
            |..:||||    |:..|.|..||.:...:.:|             ...:|:.|.|..|:
 Worm   245 KLYSIMQD----VVAARIAQREREKGAESGEP-------------QDFIDLFLDARSDDVDFSAE 292

  Fly   299 -------------KPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVL 350
                         |.||..::..:..:|:..|.|||...:|:..:.::.:||:||.:.||:....
 Worm   293 AREDFSKRNLKITKELSADEVVGQCFLFLIGGFDTTALSLSYVTYLLAVNPKIQEKVIEEIAREF 357

  Fly   351 GPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPIL-GRYIPEDLKIGEITIPGNTSILLMPYYV 414
            |   .:.|...||..|||:||||||.:||:|...|. .|...:...:..:.|.....:.:..:.:
 Worm   358 G---TSEVEFEKLGRLKYMDCVIKEALRLYPLASISNSRKCMKTTTVNGVKIEAGVYVQMDTWSL 419

  Fly   415 YRDPEYF-PDPLVFKPERWMDMKTTSNTPPL----AYIPFSSGPKNCIGQKFANLQMKALISKVI 474
            :.|||.: .|...||||||      |...||    ||:||..||:.|||.:.|.::.|.|::.::
 Worm   420 HYDPELWGEDVKEFKPERW------STDEPLEHKGAYLPFGLGPRQCIGMRLAIMEQKILLTHLL 478

  Fly   475 RHYELLPLGADLKATYTFILSSSTGNN---VGLKPR 507
            ::| ....|...:.....:.|::|...   |.|:||
 Worm   479 KNY-TFETGNKTRIPLKLVGSATTSPEDVFVHLRPR 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	109/484 (23%)
cyp-13A2	NP_496109.1	CYP3A-like	65..508	CDD:410678	111/486 (23%)