DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	136/503 - (27%)
Similarity:	252/503 - (50%)	Gaps:	78/503 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLR------PENFIQRF 60
            |:||. .:|::..::..|..    ..|:|..|.||..:|.|||   .|..|      ..:..:::
  Rat    12 WMLLA-TILVLLYLYGTSTH----GNFKKLGISGPKPLPFVGN---ILAYRHGFWEFDRHCHKKY 68

  Fly    61 GDYFNKY-GKTFRLWILGECLIYTKDLKYFESILSS------STLLKKAHLYRFLRDFLGDGLLL 118
            ||.:..| |:...|.|....:|.|..:|...|..::      :.:||||             :.|
  Rat    69 GDIWGFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSFGPAGILKKA-------------ITL 120

  Fly   119 STGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTT 183
            |...:|...|.:|:|.|....|:....|:::.:.::|:.:|:.|:....:.:.......::||.|
  Rat   121 SEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDVIT 185

  Fly   184 ETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNW---------LFPLAAPLVYRRLQ 239
            .|:.||.|::.|.|..|:.:.:|.:            :::|:         |||...| |:...
  Rat   186 GTSFGVNVDSLNNPQNPFVQKVKKL------------LKFNFLDPFFLSVILFPFLTP-VFEAF- 236

  Fly   240 KDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILL--QATID---NK 299
             ||.:   |...|::..|..:||.:.:...:.:         |.::..|.:::  |::.|   ::
  Rat   237 -DITV---FPKDVMKFFRTSVERMKENRMQEKV---------KQRLDFLQLMINSQSSGDKESHQ 288

  Fly   300 PLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLL 364
            .|:||:|..:...|||||.:||:|.:|.||:.::.||.:|:.:.:|:.:.| |: .|.||...|:
  Rat   289 GLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAAL-PN-KAPVTYDVLV 351

  Fly   365 ELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKP 429
            |::|||.|:.||:||.|....|.|...:|::|..:.||..|.:::..:.:::||:.:|:|..|.|
  Rat   352 EMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGTVVMVPTFALHKDPKCWPEPEEFCP 416

  Fly   430 ERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHY 477
            ||:. .|...:..|..|:||.:||:||||.:||.:.||..:.:|::::
  Rat   417 ERFR-KKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNF 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	128/470 (27%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	128/471 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910