Protein Alignment Cyp4d21 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 123/516 - (23%)
• Similarity: 206/516 - (39%)
• Gaps: 115/516 - (22%)

  Fly    33 ILGPFTIPIVGNGLQALTLRPENFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSST 97
            |..|  ||.:|:.: |....|..|::   :.:.|||..|...::|         |.|..:|.|..
Human    70 IFSP--IPFLGHAI-AFGKSPIEFLE---NAYEKYGPVFSFTMVG---------KTFTYLLGSDA 119

  Fly    98 L----------LKKAHLY-RFLRDFLGDGLLLSTGNK-WTSRRKVLAPAFHFKCLENFVEIMDRN 150
            .          |....:| |......|.|:.....|. :..::|:|....:....:..|.|:::.
Human   120 AALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKE 184

  Fly   151 SGIMVEKLKNYAD-----GKTCVDLFKFVSLEALDVTTET--AMGVQVNAQ-NEPNFPYTKALKS 207
            :       |.|.:     |:..|    |.:|..|.:.|.:  ..|.::.:| ||
Human   185 T-------KEYFESWGESGEKNV----FEALSELIILTASHCLHGKEIRSQLNE----------- 227

  Fly   208 VVYIESKRLASVSMRY----------NWLFPLAAPL-VYRRLQKDIAIMQDFTDKVIRERRAILE 261
                      .|:..|          .||.|...|| .:||..:....::|...|.|::||...|
Human   228 ----------KVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQE 282

  Fly   262 RARADGTYKPLIMGDDDIGGKAKMTLLDILLQATI-DNKPLSDVDIREEVDVFIFAGDDTTTSGV 325
            :.             |||        |..||.||. |.:||:|.::...:...:.||..|:::..
Human   283 KI-------------DDI--------LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTS 326

  Fly   326 SHALHAISRHPKVQECIYEELVSVLGPD-PDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRY 389
            :.....::|...:|:..|.|..:|.|.: |  .:|..:|.:|..||..||||:||.||:.|:.|.
Human   327 AWMGFFLARDKTLQKKCYLEQKTVCGENLP--PLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRM 389

  Fly   390 IPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPK 454
            ......:...|||....:.:.|....|..:.:.:.|.|.|:|::.....|. ...||:||.:|..
Human   390 ARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASG-EKFAYVPFGAGRH 453

  Fly   455 NCIGQKFANLQMKALISKVIRHYELLPLGADL------KATYTFILSSSTGNNVGLKPRTR 509
            .|||:.||.:|:|.:.|.::|.||.     ||      ...||.::.:.....:..|.|::
Human   454 RCIGENFAYVQIKTIWSTMLRLYEF-----DLIDGYFPTVNYTTMIHTPENPVIRYKRRSK 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	111/472 (24%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	113/480 (24%)