DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and CYP4B1

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens

Alignment Length:	528	Identity:	162/528 - (30%)
Similarity:	260/528 - (49%)	Gaps:	59/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MW-----ILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRF 60
            :|     ::||...||..|:    |:|......:|  ..||.|..:.|:   ||.::....:.:.
Human    15 LWASGLILVLGFLKLIHLLL----RRQTLAKAMDK--FPGPPTHWLFGH---ALEIQETGSLDKV 70

  Fly    61 GDYFNKYGKTFRLW---ILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGN 122
            ..:.:::.....||   .:|...||..|  |.:::.|... .|...:|.|...::|.|||:..|.
Human    71 VSWAHQFPYAHPLWFGQFIGFLNIYEPD--YAKAVYSRGD-PKAPDVYDFFLQWIGRGLLVLEGP 132

  Fly   123 KWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYA-DGKTCVDLFKFVSLEALDVTTETA 186
            ||...||:|.|.||:..|:.:|.:...::.||::|.:..| :||: .|:|..|...||:...:..
Human   133 KWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALNTLMKCT 196

  Fly   187 MG-VQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYN-----WLFPLAAPLVYRRLQKDIAIM 245
            .| ......:..:..|..|:..:..:..:||  ||.:|:     ||.|..     ||..:...:.
Human   197 FGRGDTGLGHSRDSSYYLAVSDLTLLMQQRL--VSFQYHNDFIYWLTPHG-----RRFLRACQVA 254

  Fly   246 QDFTDKVIRERRAIL--ERARADGTYKPLIMGDDDIGGKAKMTLLDILLQA-TIDNKPLSDVDIR 307
            .|.||:|||||:|.|  |:.|            ..|..:..:..|||||.| ..|:..|||.|:|
Human   255 HDHTDQVIRERKAALQDEKVR------------KKIQNRRHLDFLDILLGARDEDDIKLSDADLR 307

  Fly   308 EEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQ-TKLLELKYLDC 371
            .|||.|:|.|.||||||:|..|:.::.:|:.|....||:..:||   |....| ..|.::.||..
Human   308 AEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG---DQDFFQWDDLGKMTYLTM 369

  Fly   372 VIKETMRLHPPVPILGRYIPEDLK-IGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDM 435
            .|||:.||:||||.:.|.:.:.:. :...::|..:.|.:..|.::|:...:|||.||...|: ..
Human   370 CIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRF-ST 433

  Fly   436 KTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYE--LLPLGADLKATYTFILSSST 498
            :..|...|.|::|||:||:|||||:||..:||.:.:..:..:|  |.|....:|.. ..:|.|..
Human   434 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKN 497

  Fly   499 GNNVGLKP 506
            |.::.|||
Human   498 GFHLHLKP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	145/463 (31%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	150/484 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154799
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750