Protein Alignment Cyp4d21 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 133/508 - (26%)
• Similarity: 249/508 - (49%)
• Gaps: 81/508 - (15%)

  Fly     2 WILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFG-DYFN 65
            |:||.::::::.|....:.     ..|::..|.||..:|::||     .|.....:.:|. :.:.
Human    12 WLLLAVSLVLLYLYGTRTH-----GLFKRLGIPGPTPLPLLGN-----VLSYRQGLWKFDTECYK 66

  Fly    66 KYGKTFRLW-----------ILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLS 119
            ||||   :|           |....:|.|..:|...|:.::...|...       .|:...:.|:
Human    67 KYGK---MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV-------GFMKSAISLA 121

  Fly   120 TGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYAD-GK--TCVDLFKFVSLEALDV 181
            ...:|...|.:|:|.|....|:....|:.:...::|..|:..|: ||  |..|:|...|   :||
Human   122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS---MDV 183

  Fly   182 TTETAMGVQVNAQNEPNFPYTKALKSVV---YIESKRLASVSMRYNWLFPLAAPLVYRRLQ---- 239
            .|.|:.||.:::.|.|..|:.::.|..:   :::...|:.:      |||...| |:..|.
Human   184 ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSII------LFPFLTP-VFEALNVSLF 241

  Fly   240 -KDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQA-----TIDN 298
             ||..   :|..|.:..    ::::|         :.|..   |.::..|.:::.:     |..:
Human   242 PKDTI---NFLSKSVNR----MKKSR---------LNDKQ---KHRLDFLQLMIDSQNSKETESH 287

  Fly   299 KPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKL 363
            |.|||:::..:..:|||||.:||:|.:|..|:.::.||.||:.:.:|:.:|| |: .|..|...:
Human   288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PN-KAPPTYDAV 350

  Fly   364 LELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFK 428
            ::::|||.|:.||:||.|....|.|...:|::|..:.||..:.:::..|.::.||:|:.:|..|:
Human   351 VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFR 415

  Fly   429 PERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481
            |||:  .|...:..|..|.||.:||:||||.:||.:.||..:.:|::::...|
Human   416 PERF--SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	118/441 (27%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	120/443 (27%)