Protein Alignment Cyp4d21 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 132/503 - (26%)
• Similarity: 245/503 - (48%)
• Gaps: 70/503 - (13%)

  Fly     2 WILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFGDYFNK 66
            |:||.::::::.|...:|.     ..|:|..|.||..:|.:||.|.    ..:.|.....:...|
Human    12 WLLLAVSLVLLYLYGTHSH-----GLFKKLGIPGPTPLPFLGNILS----YHKGFCMFDMECHKK 67

  Fly    67 YGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLR------DFLGDGLLLSTGNKWT 125
            |||.:..:...:.::...|....:::     |:|:.:.....|      .|:...:.::...:|.
Human    68 YGKVWGFYDGQQPVLAITDPDMIKTV-----LVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWK 127

  Fly   126 SRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYAD-GK--TCVDLFKFVSLEALDVTTETAM 187
            ..|.:|:|.|....|:..|.|:.:...::|..|:..|: ||  |..|:|...|   :||.|.|:.
Human   128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS---MDVITSTSF 189

  Fly   188 GVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWL---------FPLAAPLVYRRLQKDIA 243
            ||.:::.|.|..|:.:..|.:            :|:::|         ||...|::.   ..:|.
Human   190 GVNIDSLNNPQDPFVENTKKL------------LRFDFLDPFFLSITVFPFLIPILE---VLNIC 239

  Fly   244 IMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQA-----TIDNKPLSD 303
            :........:|:....::.:|.:.|.            |.::..|.:::.:     |..:|.|||
Human   240 VFPREVTNFLRKSVKRMKESRLEDTQ------------KHRVDFLQLMIDSQNSKETESHKALSD 292

  Fly   304 VDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKY 368
            :::..:..:|||||.:||:|.:|..::.::.||.||:.:.||:.:|| |: .|..|...:|:::|
Human   293 LELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PN-KAPPTYDTVLQMEY 355

  Fly   369 LDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWM 433
            ||.|:.||:||.|....|.|...:|::|..:.||....:::..|.::|||:|:.:|..|.|||:
Human   356 LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF- 419

  Fly   434 DMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481
            ..|...|..|..|.||.|||:||||.:||.:.||..:.:|::::...|
Human   420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	124/470 (26%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	124/471 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910