DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	534	Identity:	158/534 - (29%)
Similarity:	259/534 - (48%)	Gaps:	80/534 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 W-ILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFGDYF- 64
            | .||.:.:::...|....|:||.:.|                  ||.....|.:::  :|.:.
Mouse    21 WAFLLSLFLVLFKAVQFYLRRQWLLKT------------------LQHFPCMPSHWL--WGHHLK 65

  Fly    65 NKYGKTFRLWI------LGEC--------LIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDG 115
            :|..:...:|:      ..:|        |:|..|  |.:.:|..|. .|.:.:|:|...::|.|
Mouse    66 DKELQQILIWVEKFPSACLQCLSGSNIRVLLYDPD--YVKVVLGRSD-PKASGIYQFFAPWIGYG 127

  Fly   116 LLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALD 180
            |||..|.||...|::|.||||:..|:.:|:||..:..||::|.:........:::|..|||..||
Mouse   128 LLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVNIMLDKWEKLDGQDHPLEIFHCVSLMTLD 192

  Fly   181 VTTETAMGVQVNAQNEPNFP-YTKALKSVVYIESKRLASVSMRYNWLFPLAAP--LVYRRLQKDI 242
            ...:.|...|.:.|.:.|.. ||||::.:..:...||.:...:||.::.:::.  |.:...|
Mouse   193 TVMKCAFSYQGSVQLDENSKLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQ--- 254

  Fly   243 AIMQDFTDKVIRERRA------ILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATI-DNKP 300
             |..:.||.||:.|::      .|::||.                |..:..|||||.|.: |...
Mouse   255 -IAHEHTDGVIKMRKSQLQNEEELQKARK----------------KRHLDFLDILLFARMEDRNS 302

  Fly   301 LSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLE 365
            |||.|:|.|||.|:|.|.|||.||:|...:|::.||:.|:...||:.|:||  ...|||...|.:
Mouse   303 LSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILG--DGTSVTWDHLGQ 365

  Fly   366 LKYLDCVIKETMRLHPPVPILGRYI--PEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFK 428
            :.|....|||.:||:|||..:.|.:  |.....|. :||...:..:..|.::.:|.::|:|.||.
Mouse   366 MPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGR-SIPKGITATISIYGLHHNPRFWPNPKVFD 429

  Fly   429 PERWM-DMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYT- 491
            |.|:. |....|:    ||:|||.|.:||||::||..::|..::..:..:||||....:.....
Mouse   430 PSRFAPDSSHHSH----AYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIAR 490

  Fly   492 FILSSSTGNNVGLK 505
            .:|.|..|.::.||
Mouse   491 LVLKSKNGIHLCLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	144/474 (30%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	146/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845060
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750