Protein Alignment Cyp4d21 and Cyp3a11

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_031844.1
• Gene: Cyp3a11 / 13112
• MGIID: 88609
• Length: 504
• Species: Mus musculus
• Alignment Length: 502
• Identity: 134/502 - (26%)
• Similarity: 250/502 - (49%)
• Gaps: 67/502 - (13%)

  Fly     2 WILLGIAVLIMTLVWDNSRKQWRVNT-----FEKSRILGPFTIPIVGNGLQALTLRPENFIQRFG 61
            |:||.|:::::          :|..|     |:|..|.||..:|.:|..|        |:.:...
Mouse    12 WVLLAISLVLL----------YRYGTRKHELFKKQGIPGPKPLPFLGTVL--------NYYKGLW 58

  Fly    62 DY----FNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDF-----LGDGLL 117
            .:    :.|||||:.|:.....|:...|.:..:::|.....    .::...|||     :...:.
Mouse    59 KFDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECF----SVFTNRRDFGPVGIMSKAIS 119

  Fly   118 LSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVT 182
            :|..::|...|.:|:|.|....|:....::::...|:|:.|:..|.....|.:...:...::||.
Mouse   120 ISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVI 184

  Fly   183 TETAMGVQVNAQNEPNFPYTKALKSVVYIE--SKRLASVSMRYNWLFPLAAPLVYRRLQ-----K 240
            |.|:.||.|::.|.|..|:.:..|.::..:  ...|.||.     |||...| ||..|.     |
Mouse   185 TSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVV-----LFPFLTP-VYEMLNICMFPK 243

  Fly   241 D-IAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDV 304
            | |...:.|.|::...|....::.|.|  :..|:|...: ..|.|           :.:|.|||:
Mouse   244 DSIEFFKKFVDRMKESRLDSKQKHRVD--FLQLMMNSHN-NSKDK-----------VSHKALSDM 294

  Fly   305 DIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYL 369
            :|..:..:|||||.:||:|.:|..||:::.||.:|:.:.:|:...| |: .|..|...::|::||
Mouse   295 EITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEAL-PN-KAPPTYDTVMEMEYL 357

  Fly   370 DCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMD 434
            |.|:.||:||:|....|.|...:|:::..:.||..:::::..|.::.||:::.:|..|:|||: .
Mouse   358 DMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERF-S 421

  Fly   435 MKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481
            .:...:..|..|:||.:||:||:|.:||.:.||..::|:::::...|
Mouse   422 KENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQP 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	117/427 (27%)
Cyp3a11	NP_031844.1	CYP3A	67..493	CDD:410743	119/429 (28%)