DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	535	Identity:	167/535 - (31%)
Similarity:	266/535 - (49%)	Gaps:	65/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WILLGIA----VLIMTLVW-----DNSRKQWRVNTFEKSR----ILGPF-TIPIVGNGLQALT-- 50
            |:||.:.    :|...|.|     .|.|   |:..|.:.|    .||.. .:.....||:.||
Human    19 WLLLLVVGASWLLARILAWTYAFYHNGR---RLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQL 80

  Fly    51 --LRPENFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLL--KKAHLYRFLRDF 111
              ..|:.|::..|....         |:..|   ..|:  ..|::::|..:  |....|:.|:.:
Human    81 VATYPQGFVRWLGPITP---------IINLC---HPDI--VRSVINTSDAITDKDIVFYKTLKPW 131

  Fly   112 LGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYA-DGKTCVDLFKFVS 175
            ||||||||.|:||...|::|.|||||..|:.:::|..:::.||..|.:..| :|.||:|:|:.:|
Human   132 LGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHIS 196

  Fly   176 LEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYN----WLFPLAAPLVYR 236
            |..||...:.......|.|.:|: .|..|:..:..:..|| .:...||.    :|.|..     |
Human   197 LMTLDSLQKCIFSFDSNCQEKPS-EYITAIMELSALVVKR-NNQFFRYKDFLYFLTPCG-----R 254

  Fly   237 RLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----ILLQATID 297
            |..:...::.||||.||:|||..|   .:.|.       ||.:..|||...||    :||....:
Human   255 RFHRACRLVHDFTDAVIQERRRTL---TSQGV-------DDFLQAKAKSKTLDFIDVLLLSEDKN 309

  Fly   298 NKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTK 362
            .|.|||.|||.|.|.|:|.|.|||.||:|..|:.::|||:.||...:|:..:|.......:....
Human   310 GKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDD 374

  Fly   363 LLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEI-TIPGNTSILLMPYYVYRDPEYFPDPLV 426
            |.:|.:|...:||::|||||:|...|...:|:.:.:. .||......:..:.::.:|..:|||.|
Human   375 LAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEV 439

  Fly   427 FKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYT 491
            :.|.|: |.:......|:|:||||:||:||||||||..:||.:::..:..:.:||...:.:.|..
Human   440 YDPFRF-DPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPE 503

  Fly   492 FILSSSTGNNVGLKP 506
            .:|.:..|..:.::|
Human   504 IVLRAEDGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	150/463 (32%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	154/483 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154727
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750