DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	532	Identity:	171/532 - (32%)
Similarity:	270/532 - (50%)	Gaps:	52/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WILLGIAVLIMTLVWDNSRKQWRVNTFEKS-RILGPFTIPIVGN---GLQALTLRPENFIQRFGD 62
            |:||    |::...|..:|...:...|.:: ..|..|..|...|   |...:....|:.::...:
Mouse    24 WLLL----LLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWFLGHLGMITPTEHGLKEVTN 84

  Fly    63 YFNKYGKTFRLWILGECL-IYT---KDLKYFESIL--SSSTLLKKAHLYRFLRDFLGDGLLLSTG 121
            ....|.:.|..| ||..: |.|   .|:  ..|:|  |:|..||:...|.||:.:||||||||.|
Mouse    85 LVATYPQGFMTW-LGPIIPIITLCHPDI--IRSVLNASASVALKEVVFYSFLKPWLGDGLLLSDG 146

  Fly   122 NKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTC-VDLFKFVSLEALDVTTET 185
            :||:|.|::|.|||||..|:.:|:|.:.::.||..|.::.|.|.:. :|:|:.:||..||...:.
Mouse   147 DKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQHLASGGSARLDVFENISLMTLDSLQKC 211

  Fly   186 AMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTD 250
            ......|.|..|: .|..|:..:..:.:||...:.:..:.|:.|...  .||..|...::..|||
Mouse   212 VFSFDSNCQENPS-EYISAILELSALVTKRYHQLLLHIDSLYQLTCS--GRRFHKACHLVHSFTD 273

  Fly   251 KVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----ILLQATIDNKPLSDVDIREEVD 311
            .||::||..|          |....||.:..|||...||    :||....|.|.|||.|||.|.|
Mouse   274 AVIQDRRRTL----------PSKHEDDVLKAKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEAD 328

  Fly   312 VFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTK----------LLEL 366
            .|:|.|.|||.||:|..|:.::|||:.||...:|:..:|   .|...|:.:          |.:|
Mouse   329 TFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELL---RDRESTEIECSCAVFLRDDLAQL 390

  Fly   367 KYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPEYFPDPLVFKP 429
            .:|...|||::||||||.::.|...:|:.:  |.: ||.....::..:..:.:|..:|||.|:.|
Mouse   391 PFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRV-IPKGVICIINIFATHHNPTVWPDPEVYDP 454

  Fly   430 ERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFIL 494
            .|: |.:...:..|||:||||:||:|||||.||..:||..::..:..:.:||...:.:.....||
Mouse   455 FRF-DPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELIL 518

  Fly   495 SSSTGNNVGLKP 506
            .:..|..:.::|
Mouse   519 RAEGGLWLRVEP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	158/472 (33%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	161/489 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750