Protein Alignment Cyp4d21 and Cyp27a1

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_077226.2
• Gene: Cyp27a1 / 104086
• MGIID: 88594
• Length: 533
• Species: Mus musculus
• Alignment Length: 570
• Identity: 140/570 - (24%)
• Similarity: 234/570 - (41%)
• Gaps: 139/570 - (24%)

  Fly    16 WDNSRKQWRVNTFEKSRILG----------PFTIPIV----------GNGLQALTLR-----PEN 55
            |..:|.:|   |....|::|          ..|||..          |.|.....||     |..
Mouse     4 WSRTRLRW---TLLDPRVVGRGLCPQGARAKATIPAALQAQESTEGPGTGQDRPRLRSPAELPGT 65

  Fly    56 FIQRFGDYFNKYGKTFRLWILGECLIYTKDLK-----------------YFESILSSSTLLKKA- 102
            ...:|         .|:|::.| .:::..||:                 |....|:|:.||::.
Mouse    66 GTLQF---------LFQLFLQG-YVLHLPDLQVLNKTKYGPMWTTSFGTYTNVNLASAPLLEQVM 120

  Fly   103 ----------HL--YRFLRDFLG--DGLLLSTGNKW-----TSRRKVLAP---AFHFKCL----E 141
                      |:  ::..||..|  .|:.::.|.:|     ..::::|.|   |.:...|    .
Mouse   121 RQEGKYPIRDHMDQWKDHRDHKGLTYGIFIAQGEQWYHLRQALKQRLLKPDEAALYTDALNEVIS 185

  Fly   142 NFVEIMDR-----NSGIMVEKLKNYADGKTCVDLFKFVSLEALD-VTTETAMGVQVNAQNEPNFP 200
            :|:..:|:     .||..|..:.:         |...::|||:. :..|..:|..     :|:.|
Mouse   186 DFITRLDQVRAESESGDQVPDMAH---------LLYHLALEAITYILFEKRIGCL-----KPSIP 236

  Fly   201 Y-TKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRL---QKDIAIMQDFTDKVIRERRAILE 261
            . |.|....|.|..:....::....|..|| .|...|.|   ....:..:...|:.::|.:|.|:
Mouse   237 EDTAAFIRSVAIMFQNSVYITFLPKWTRPL-LPFWKRYLNGWDNIFSFGKKLIDEKVQELKAQLQ 300

  Fly   262 RARADGTYKPLIMGDDDIGGKAKMTLLDILL--QATIDNKPLSDVDIREEVDVFIFAGDDTTTSG 324
            ....||.         .:.|.....|.:.||  |.||...|           ..:.||.|||::.
Mouse   301 ETGPDGV---------RVSGYLHFLLTNELLSTQETIGTFP-----------ELLLAGVDTTSNT 345

  Fly   325 VSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTK-LLELKYLDCVIKETMRLHPPVPILGR 388
            ::.||:.:|:.|::||.:::|:..|:   |...|.|.| ...:..|..|||||:||:|.||...|
Mouse   346 LTWALYHLSKSPEIQEALHKEVTGVV---PFGKVPQHKDFAHMPLLKAVIKETLRLYPVVPTNSR 407

  Fly   389 YIPE-DLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSN---TPPLAYIPF 449
            .|.| :.:|.....|.||..:|..|.|.|||..||:|..|:|.||:..|...|   ..|...:||
Mouse   408 IITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPNSFQPHRWLRKKEADNPGILHPFGSVPF 472

  Fly   450 SSGPKNCIGQKFANLQMKALISKVIRHYE--LLPLGADLKATYTFILSSS 497
            ..|.::|:|::.|.|:|:.::|::::.||  |.|...::|.....:|..|
Mouse   473 GYGVRSCLGRRIAELEMQLMLSRLVQKYEIALAPGMGEVKTVSRIVLVPS 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	125/493 (25%)
Cyp27a1	NP_077226.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..60		6/25 (24%)
		cytochrome_P450	91..527	CDD:477761	120/470 (26%)
		Sterol-binding. /evidence=ECO:0000255	386..400		8/13 (62%)