DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	518	Identity:	158/518 - (30%)
Similarity:	263/518 - (50%)	Gaps:	49/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGN---GLQALTLRPENFIQRFGDYF 64
            :.|.:|.|:..||         .......|.|..|..|.:.|   |...|....|..:||..|..
Zfish    11 LALSVAALLCALV---------TRIIINRRALRCFNQPPLRNWIMGHMGLMGHNEEGLQRVDDLV 66

  Fly    65 NKYGKTFRLWILGE----CLIYTKDLKYFESIL--SSSTLLKKAHLYRFLRDFLGDGLLLSTGNK 123
            .|||.:.. |.||.    ..::..|  |..|:|  |:|..||....|.|::.:||:.|||.:|.:
Zfish    67 CKYGHSCS-WFLGPFYNMVRLFHPD--YIRSLLTASASITLKDRIFYGFMKPWLGNCLLLQSGQE 128

  Fly   124 WTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKN-YADGKTCVDLFKFVSLEALDVTTETAM 187
            |:..|::|.|||||..|:.:|.|.::::.||.::.:. .|.|:..||:|:.:|...||...:...
Zfish   129 WSRHRRLLTPAFHFDILKKYVHIFNQSTNIMHDEWRRLLAKGEHSVDMFEQISSLTLDSLLKCTF 193

  Fly   188 GVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKV 252
            ....::|.:|. .|..|:..:..:..:|...:...::||:..:|.  .||.|:..|::..||..:
Zfish   194 SCDTHSQEKPR-QYISAILDLSRLLVQRQHYLPYHWDWLYWRSAQ--GRRFQQACAVVHQFTADI 255

  Fly   253 IRERRAILERARAD--------GTYKPLIMGDDDIGGKAKMT-LLDILLQATID-NKPLSDVDIR 307
            ::|||..|:: ::|        |.|:           |.|.| |:|:||.|..| .:.|::.:|:
Zfish   256 VQERRTQLDQ-QSDPESHPENTGRYR-----------KRKNTDLIDLLLLAKDDKGEGLTNEEIK 308

  Fly   308 EEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCV 372
            ...|:|:|||.|||.|.:|...:.::.:...||....|:..:|......::....|.:|.:....
Zfish   309 AHADMFMFAGHDTTASALSWIFYNLAMNQDYQERCRAEVRDLLADRDTHTIGWEDLSQLTFTTMC 373

  Fly   373 IKETMRLHPPVPILGRYIPEDLKI-GEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMK 436
            |||::|||.||..|.||..:::|. |:..||.....|:..|.|:|:|:.:||||||.|.|: |..
Zfish   374 IKESLRLHSPVLALTRYYSQNMKTPGDCVIPHGCLCLISIYGVHRNPQVWPDPLVFDPTRF-DPH 437

  Fly   437 TTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFILSSSTG 499
            .:.:..|.|:||||:||:|||||.||..:||.:::..:..:::||....::..|..:|.:..|
Zfish   438 NSDSRSPHAFIPFSAGPRNCIGQNFAMAEMKVVVALTLARFKILPGPKPVRRLYQLVLRAEGG 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	147/467 (31%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	150/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010