DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and SERPINA6

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001747.3	Gene:	SERPINA6 / 866	HGNCID:	1540	Length:	405	Species:	Homo sapiens

Alignment Length:	407	Identity:	96/407 - (23%)
Similarity:	184/407 - (45%)	Gaps:	67/407 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YLYLLLLATSVESGFWE-------------------------DF----YRILASQNAKRNLIYSP 38
            |..||.|.|   ||.|.                         ||    |:.|.:.:.|:|:..||
Human     6 YTCLLWLPT---SGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISP 67

  Fly    39 ISAEIIMSMVYMASGGKTFEELRNVLKFS---ENKTLVANNYRSLLSDLKRRETFIILHMANRIY 100
            :|..:.::|:.:.:.|.|..:|...|.|:   .::|.:...::.|.....:.:|.:.:.|.|.::
Human    68 VSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALF 132

  Fly   101 VNKKYCLVPEFNQLARKAFKAKAKSIRLDDPVSASAIVNSWILNRTRGMIRNIVLPKDFNSDTSA 165
            ::....|:..|:...:..::::..::...|..:||..:||::.|:|:|.|  :.|....:|....
Human   133 LDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKI--VDLFSGLDSPAIL 195

  Fly   166 FLVNAIYFKGQWLYNFKADQTHIADFYVSANEIIPVKMMTLSASLLSGYIDDIDAKIIELPY-WN 229
            .|||.|:|||.|...|....|...:|||....::.|.||..|:::...:..::..:::::.| .|
Human   196 VLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGN 260

  Fly   230 STLSMRIILPNSVDGLRKLKEKVGFIDYHLEKKSVN------------VKLPKFKIESKAQLKGI 282
            .|:.  .|||:        |.|:..:...|.:.::|            :.:||..|.....|..:
Human   261 GTVF--FILPD--------KGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDV 315

  Fly   283 FENLGILDVFKPSADLNGLVLESGAKIDKIVQKAFLKIDEKGGEASAATGVLTRRKKSIDNLIQP 347
            .|.:||.|:|...|:.:.:..::..|..|:|.||.|:::|:|.:.:.:|||..       ||...
Human   316 LEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTL-------NLTSK 373

  Fly   348 PMEFIADHPFFYVIHDN 364
            |:....:.||..:|.|:
Human   374 PIILRFNQPFIIMIFDH 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	89/393 (23%)
SERPINA6	NP_001747.3	alpha-1-antitrypsin_like	42..401	CDD:239011	88/368 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020