DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and SERPINA7

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	XP_006724746.1	Gene:	SERPINA7 / 6906	HGNCID:	11583	Length:	425	Species:	Homo sapiens

Alignment Length:	437	Identity:	94/437 - (21%)
Similarity:	179/437 - (40%)	Gaps:	81/437 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YLYLLLLA-------------------------------TSVESGFWEDFYRILASQNAKRNLIY 36
            :|||:||.                               :|:.:.|..:.||....:...:|:.:
Human     4 FLYLVLLVLGLHATIHCASPEGKVTACHSSQPNATLYKMSSINADFAFNLYRRFTVETPDKNIFF 68

  Fly    37 SPISAEIIMSMVYMASGGKTFEELRNVLKFSENKT---LVANNYRSLLSDLKRRETFIILHMANR 98
            ||:|....:.|:...:...|..|:...|.|:...|   .:.:.::.|:..|...:..:.|.:.|.
Human    69 SPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNA 133

  Fly    99 IYVNKKYCLVPEFNQLARKAFKAKAKSIRLDDPVSASAIVNSWILNRTRGMIRNIVLPKDFNSDT 163
            :::.|....:.:|....:..::.:..|....:..:|...:||.:..:|:|.:..::  :|...:|
Human   134 LFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLI--QDLKPNT 196

  Fly   164 SAFLVNAIYFKGQWLYNFKADQTH-IADFYVSANEIIPVKMMTLSASLLSGY---ID-DIDAKII 223
            ...|||.|:||.||...|...:|. .:.|.:.....:.|.||    ..:..|   :| :::..::
Human   197 IMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMM----HQMEQYYHLVDMELNCTVL 257

  Fly   224 ELPYWNSTLSMRIILP-----NSVDGLRKLK--EKVGFIDYHLEKKSVNVKLPKFKIESKAQLKG 281
            ::.|..:.|:: .:||     .||:.....|  :|...:   |:|..|::.:|||.|.:...|..
Human   258 QMDYSKNALAL-FVLPKEGQMESVEAAMSSKTLKKWNRL---LQKGWVDLFVPKFSISATYDLGA 318

  Fly   282 IFENLGILDVFKPSADLNGLVLESGAKID----------KIVQKAFLKIDEKGGEASAATGVLTR 336
            ....:||...:..:||.:||..::|.|:.          :...||.|.|.|||.||:|.
Human   319 TLLKMGIQHAYSENADFSGLTEDNGLKLSNRPAGFVLPTQAAHKAVLHIGEKGTEAAAV------ 377

  Fly   337 RKKSIDNLIQPPMEFI-----ADHPFFYVI--HDNKVIYFQGHIVEP 376
              ..::...||...|:     .|..|..:|  ...:.|.|.|.:|.|
Human   378 --PEVELSDQPENTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNP 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	86/387 (22%)
SERPINA7	XP_006724746.1	alpha-1-antitrypsin_like	46..419	CDD:239011	86/390 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010