DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and Serpina5

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001231668.1	Gene:	Serpina5 / 65051	RGDID:	619817	Length:	442	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	107/381 - (28%)
Similarity:	189/381 - (49%)	Gaps:	26/381 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LATSVESGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFS---ENK 70
            :.||....|....||.|||:...:|:.:||:|..:.:.|:.:.||.||..::...|..|   ..:
  Rat    75 VGTSRSRDFAFRLYRALASEAPGQNVFFSPMSVSMSLGMLSLGSGLKTKAQILEGLGLSLQQGQE 139

  Fly    71 TLVANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDDPVSAS 135
            .::...::.||....:....:.|.:.:.::.:....:...|....:..:.:...|....:|.||.
  Rat   140 DMLHKGFQQLLQQFSQPSDGLQLSLGSALFTDPAVHIRDHFLSAMKTLYMSDMFSTNFGNPESAK 204

  Fly   136 AIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSANEIIP 200
            ..:|.::..:|.|.|.:::  ||.:|.....:||.|:||.:|...|.:..||..|::|:..:.|.
  Rat   205 KQINDYVAKKTNGKIVDLI--KDLDSTHVMVVVNYIFFKAKWQTAFSSTNTHKMDYHVTPKKTIQ 267

  Fly   201 VKMMTLSASLLSGYID-DIDAKIIELPYWNSTLSMRIILPNS------VDGL--RKLKEKVGFID 256
            |.||. ...:.|..:| :|...::.:||..:|.:: .|||:.      .|||  |.|:..:..
  Rat   268 VPMMN-REDIYSYILDQNISCTVVGIPYQGNTFAL-FILPSEGKMKRVEDGLDERTLRNWLKM-- 328

  Fly   257 YHLEKKSVNVKLPKFKIESKAQLKGIFENLGILDVFKPSADLNGLVLESGAKIDKIVQKAFLKID 321
              ..|:.:::.||||.||...:|:.|...|||.|:|...|||:||...:..|:.::|.|:.:::|
  Rat   329 --FTKRQLDLYLPKFSIEGTYKLEKILPKLGIQDIFTTHADLSGLTDHTNIKLSEMVHKSMVEVD 391

  Fly   322 EKGGEASAATGVL-TRRKKSIDNLIQPPMEFIADHPFFYVIHDNKVIYFQGHIVEP 376
            |.|..|:|:||:| |.|.....:|   .:||  ..||..||.|...:||.|.:::|
  Rat   392 ESGTTAAASTGILFTLRSARPSSL---KVEF--TRPFLVVIMDGTNLYFIGKVIQP 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	104/368 (28%)
Serpina5	NP_001231668.1	alpha-1-antitrypsin_like	81..439	CDD:239011	104/370 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010