DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and serpini1

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001122164.1	Gene:	serpini1 / 557627	ZFINID:	ZDB-GENE-060503-390	Length:	415	Species:	Danio rerio

Alignment Length:	405	Identity:	118/405 - (29%)
Similarity:	203/405 - (50%)	Gaps:	45/405 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLL------ATSVESGFWEDF----YRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEEL 60
            ||||      |:.|......:|    |..|...:.:.|:|:||:|..:.:.||.:.:.|.:.:|:
Zfish    10 LLLLRGCFCQASDVPEDVTAEFSVRLYHQLQISSGEENIIFSPLSVALALGMVELGARGSSLQEI 74

  Fly    61 RNVLKFS-----ENKTLVANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFK 120
            |..:.:|     |..:|:.|..::|.:|    |...::.:||.:::........:|.||.:|.|:
Zfish    75 RQAVGYSHFREDEEFSLLRNLSQALSTD----EEQYVVRLANSLFLQSGVHFNEDFLQLMKKYFR 135

  Fly   121 AKAKSIRLDDPVSASAIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQ 185
            |:.:::......:.:..:|||:||.|...|:|:|..:||:|.|...||||:||:|.|...|:.:.
Zfish   136 AEVETVDFSQSTAVAERINSWVLNHTESKIQNLVSAEDFSSSTMIMLVNAVYFRGSWKNQFRPEN 200

  Fly   186 THIADFYVSANEIIPVKMMTLSASLLSGYIDD--IDA----KIIELPYWNSTLSMRIILPNSVDG 244
            |....|.......:...||........|...|  .:|    :::|:.|....:||.|:||.....
Zfish   201 TRTFSFTRDDGSEVQTLMMYQQGDFYYGEFSDGTTEAGGVYQVLEMLYEGEDMSMMIVLPRQEVP 265

  Fly   245 LRKLKE--KVGFID---YHLEKKSVNVKLPKFKIESKAQLKGIFENLGILDVFKPSADLNGLVLE 304
            |..|:.  |...::   .:::::.|.|.||:||:|.|..|:...:.|||..:|...|||:.:..:
Zfish   266 LASLEPIIKAPLLEEWANNVKRQKVEVYLPRFKVEQKIDLRESLQQLGIRSIFSKDADLSAMTAQ 330

  Fly   305 ----SGAKIDKIVQKAFLKIDEKGGEASAATGV--LTRRKKSIDNLIQPPMEFIADHPFFYVIHD 363
                ....|.|.||||:|::.|:|.|.:|.:|:  |||      .|:..| :.:||||||::|.:
Zfish   331 MTDGQDLFIGKAVQKAYLEVTEEGAEGAAGSGMIALTR------TLVLYP-QVMADHPFFFIIRN 388

  Fly   364 NKV--IYFQGHIVEP 376
            .|.  |.|.|.::.|
Zfish   389 RKTGSILFMGRVMNP 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	111/383 (29%)
serpini1	NP_001122164.1	SERPIN	25..414	CDD:294093	112/390 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930