Protein Alignment Spn28B and SERPINB10

DIOPT Version :9

• Sequence 1: NP_001260209.1
• Gene: Spn28B / 34035
• FlyBaseID: FBgn0083141
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_005015.1
• Gene: SERPINB10 / 5273
• HGNCID: 8942
• Length: 397
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 114/404 - (28%)
• Similarity: 196/404 - (48%)
• Gaps: 46/404 - (11%)

  Fly     9 LATSVESGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFS------ 67
            ||||:.. |..:..:.||.....:|:.:|..|....:::||:.:.|.|..::..||:|:
Human     4 LATSINQ-FALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVK 67

  Fly    68 ---------------ENKTLVANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARK 117
                           .|...:.:::::|:|::.:.....:|..||.||..|.|....::.:..:.
Human    68 CDPESEKKRKMEFNLSNSEEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYAFHNKYLEDMKT 132

  Fly   118 AFKAKAKSIRLDDPVSAS----AIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWL 178
            .|.|:.:.:..   |.||    ..:|||:..:|.|.|:|::.....:|.|...||||:||||.|.
Human   133 YFGAEPQPVNF---VEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNALYFKGIWE 194

  Fly   179 YNFKADQTHIADFYVSANEIIPVKMMTLSASLLSGYIDDIDAKIIELPYWNSTLSMRIILPNSVD 243
            :.|....|....|.::.....||:||.:...|...:|:...|..::|.|.:..||:.|:||..::
Human   195 HQFLVQNTTEKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPEDIN 259

  Fly   244 GLRKLKEKVGFIDYH-------LEKKSVNVKLPKFKIESKAQLKGIFENLGILDVFKPS-ADLNG 300
            ||.:|::.:.:...:       :|...|.:.|||||:|....||....::|:.|.|..| ||.:|
Human   260 GLEQLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQSKADFSG 324

  Fly   301 LVLESGAKIDKIVQKAFLKIDEKGGEASAATGVLTRRKKSIDNLIQ-PPMEFIADHPFFYVIHDN 364
            :.......:..:..|||::|:|:|.||:|.:|      ..||..|: |.:||.|:|||.:.|..|
Human   325 MSSARNLFLSNVFHKAFVEINEQGTEAAAGSG------SEIDIRIRVPSIEFNANHPFLFFIRHN 383

  Fly   365 K--VIYFQGHIVEP 376
            |  .|.|.|.:..|
Human   384 KTNTILFYGRLCSP 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	109/391 (28%)
SERPINB10	NP_005015.1	PAI-2	4..397	CDD:239013	113/402 (28%)
		Nuclear localization signal	74..77		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830