DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and SERPINF1

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001316832.1	Gene:	SERPINF1 / 5176	HGNCID:	8824	Length:	418	Species:	Homo sapiens

Alignment Length:	392	Identity:	95/392 - (24%)
Similarity:	175/392 - (44%)	Gaps:	52/392 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LATSVESGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFSENKTLV 73
            ||.:| |.|..|.||:.:|.:...|::.||:|....:|.:.:.:..:|...:...|.:.    |:
Human    54 LAAAV-SNFGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYD----LI 113

  Fly    74 AN-----NYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSI----RLD 129
            ::     .|:.||..:...:.  .|..|:||...||..:...|.....|::..:.:.:    |||
Human   114 SSPDIHGTYKELLDTVTAPQK--NLKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPRLD 176

  Fly   130 DPVSASAIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVS 194
                 ...:|:|:..:.:|.:....  |:...:.|..|:...:|||||:..|.:.:|.:.|||:.
Human   177 -----LQEINNWVQAQMKGKLARST--KEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYLD 234

  Fly   195 ANEIIPVKMMT-LSASLLSGYIDDIDAKIIELPYWNSTLSMRIILPNSV-DGLRKLKEKV--GFI 255
            ....:.|.||: ..|.|..|...|:..||.:||...| :|:...||..| ..|..::|.:  .||
Human   235 EERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGS-MSIIFFLPLKVTQNLTLIEESLTSEFI 298

  Fly   256 -DYHLEKKSVNVKL--PKFKIESKAQLKGIFENLGILDVFKPSADLNGLVLESGAKIDKIVQKAF 317
             |...|.|:|...|  ||.|:..:.::....:.:.:..:| .|.|.: .:.....|:.::..:|.
Human   299 HDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLF-DSPDFS-KITGKPIKLTQVEHRAG 361

  Fly   318 LKIDEKGGEASAATGVLTRRKKSIDNLIQP-----PMEFIADHPFFYVIHDNK--VIYFQGHIVE 375
            .:.:|.|...:.:.|            :||     |:::..:.||.:|:.|..  .:.|.|.|::
Human   362 FEWNEDGAGTTPSPG------------LQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILD 414

  Fly   376 PR 377
            ||
Human   415 PR 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	88/378 (23%)
SERPINF1	NP_001316832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		PEDF	40..415	CDD:239007	93/389 (24%)
		O-glycosylated at one site	371..383		3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010