Protein Alignment Spn28B and SERPINA5

DIOPT Version :10

• Sequence 1: NP_609128.2
• Gene: Spn28B / 34035
• FlyBaseID: FBgn0083141
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_000615.3
• Gene: SERPINA5 / 5104
• HGNCID: 8723
• Length: 406
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 104/388 - (26%)
• Similarity: 186/388 - (47%)
• Gaps: 41/388 - (10%)

  Fly     9 LATSVESGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEEL-----RNVLKFSE 68
            :|.|....|..|.||.|||....:::.:||:|..:.::|:.:.:|..|..::     .|:.|.||
Human    40 VAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSE 104

  Fly    69 NKTLVANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDDPVS 133
            .:  :...::.||.:|.:......|.:.|.::.:....|...|....:..:.|........|...
Human   105 KE--LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAG 167

  Fly   134 ASAIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSANEI 198
            |...:|.::..:|:|.|  :.|.|:.:|:....:||.|:||.:|..:|....|...||||::..:
Human   168 AMKQINDYVAKQTKGKI--VDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETV 230

  Fly   199 IPVKMMTLSASLLSGYIDD--IDAKIIELPYWNSTLSMRIILPN-----------SVDGLRK-LK 249
            :.|.||:.....  .|:.|  :..:::.:||..:..:: .|||:           |...||| ||
Human   231 VRVPMMSREDQY--HYLLDRNLSCRVVGVPYQGNATAL-FILPSEGKMQQVENGLSEKTLRKWLK 292

  Fly   250 EKVGFIDYHLEKKSVNVKLPKFKIESKAQLKGIFENLGILDVFKPSADLNGLVLESGAKIDKIVQ 314
                    ..:|:.:.:.||||.||...||:.:..:|||.:||...|||:|:...|..::.::|.
Human   293 --------MFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVH 349

  Fly   315 KAFLKIDEKGGEASAATG-VLTRRKKSIDNLIQPPMEFIADHPFFYVIHDNKVIYFQGHIVEP 376
            ||.:::||.|..|:|||| :.|.|...:::     ...:.:.||...|.||.:: |.|.:..|
Human   350 KAVVEVDESGTRAAAATGTIFTFRSARLNS-----QRLVFNRPFLMFIVDNNIL-FLGKVNRP 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_609128.2	serpin42Dd-like_insects	12..376	CDD:381070	102/383 (27%)
SERPINA5	NP_000615.3	serpinA5_PCI	44..406	CDD:381021	101/382 (26%)