Protein Alignment Spn28B and SERPINE1

DIOPT Version :10

• Sequence 1: NP_609128.2
• Gene: Spn28B / 34035
• FlyBaseID: FBgn0083141
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_001373389.1
• Gene: SERPINE1 / 5054
• HGNCID: 8583
• Length: 492
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 98/378 - (25%)
• Similarity: 177/378 - (46%)
• Gaps: 37/378 - (9%)

  Fly     5 YLLLLATSVESGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFS-E 68
            |:..||    |.|....::.:|..:..||:::||.....:::|:.:.:||:|.::::..:.|. :
Human    30 YVAHLA----SDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKID 90

  Fly    69 NKTL---VANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDD 130
            :|.:   :.:.|:.|:....:.|    :...:.|:|.:...||..|.....:.|::..|.:...:
Human    91 DKGMAPALRHLYKELMGPWNKDE----ISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSE 151

  Fly   131 PVSASAIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSA 195
            ...|..|:|.|:...|:|||.|::.....:..|...||||:||.|||...|....||...|:.|.
Human   152 VERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSD 216

  Fly   196 NEIIPVKMMT-------LSASLLSGYIDDIDAKIIELPYWNSTLSMRIILPNS----VDGLRKL- 248
            ...:.|.||.       ...:...|:..|    |:||||...||||.|..|..    :..|..:
Human   217 GSTVSVPMMAQTNKFNYTEFTTPDGHYYD----ILELPYHGDTLSMFIAAPYEKEVPLSALTNIL 277

  Fly   249 -KEKVGFIDYHLEKKSVNVKLPKFKIESKAQLKGIFENLGILDVFKP-SADLNGLVLESGAKIDK 311
             .:.:.....::.:....:.||||.:|::..|:...||||:.|:|:. .||...|..:....:.:
Human   278 SAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQ 342

  Fly   312 IVQKAFLKIDEKGGEASAATGVLTRRKKSIDNLIQPPMEFIADHPFFYVIHDN 364
            .:||..::::|.|..||::|.|:...:.:       |.|.|.|.||.:|:..|
Human   343 ALQKVKIEVNESGTVASSSTAVIVSARMA-------PEEIIMDRPFLFVVRHN 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_609128.2	serpin42Dd-like_insects	12..376	CDD:381070	95/371 (26%)
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	98/378 (26%)