DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and SERPINA2

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_006211.2	Gene:	SERPINA2 / 390502	HGNCID:	8985	Length:	421	Species:	Homo sapiens

Alignment Length:	409	Identity:	110/409 - (26%)
Similarity:	179/409 - (43%)	Gaps:	77/409 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ESGFWE----------------DFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRN 62
            :.|.||                |.|:.||..:...|::.:|.|..:..:|:.:.:...|..|:..
Human    41 DQGDWEDLACQKISYNVTDLAFDLYKELADLSQTSNVLVTPTSVAMAFAMLSLGTKADTRTEILE 105

  Fly    63 VLKFSENKT---LVANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAK 124
            .|..:..:|   .:...::.:|..|.|.:|.:.|...:.::|||...||..|.:..:|.:.::|.
Human   106 GLNVNLTETPEAKIHECFQQVLQALSRPDTRLQLTTGSSLFVNKSMKLVDTFLEDTKKLYHSEAS 170

  Fly   125 SIRLDDPVSASAIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIA 189
            ||...|...|...:|:::..||...:.::|  |....|||..||:.|.|.|:|...|||:...:.
Human   171 SINFRDTEEAKEQINNYVEKRTGRKVVDLV--KHLKKDTSLALVDYISFHGKWKDKFKAEHIMVE 233

  Fly   190 DFYVSANEIIPVKMMTLSASLLSGYIDDIDA-KIIELPYW--------NSTLSMRIILPNSVDGL 245
            .|:|....||.|.|:        .::...|. :..||..|        |:|..  .|||:. ..:
Human   234 GFHVDDKTIIRVPMI--------NHLGRFDIHRDRELSSWVLAQHYVGNATAF--FILPDP-KKM 287

  Fly   246 RKLKEKVGFIDYHLEK-------KSVNVKLPKFKIESKAQLKGIFENLGILDVFKPSADLNGLVL 303
            .:|:||:.:  .|||.       :|:|:..||..|....:||.:..||||..:|...|||:|:..
Human   288 WQLEEKLTY--SHLENIQRAFDIRSINLHFPKLSISGTYKLKRVLRNLGITKIFSNEADLSGVSQ 350

  Fly   304 ESGAKIDKIVQKAFLKIDEKGGEASAATGVLTRRKKSIDNLIQPPME---------FIADHPFFY 359
            |:..|:.|.|..|.|.|||||.||:.|                |.:|         .:.:.||..
Human   351 EAPLKLSKAVHVAVLTIDEKGTEATGA----------------PHLEEKAWSKYQTVMFNRPFLV 399

  Fly   360 VIHDNKVIY--FQGHIVEP 376
            :|.|:...:  |.|.:|.|
Human   400 IIKDDITNFPLFIGKVVNP 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	107/401 (27%)
SERPINA2	NP_006211.2	SERPIN	62..418	CDD:214513	106/386 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010