Protein Alignment Spn28B and SERPINA2

DIOPT Version :10

• Sequence 1: NP_609128.2
• Gene: Spn28B / 34035
• FlyBaseID: FBgn0083141
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_006211.2
• Gene: SERPINA2 / 390502
• HGNCID: 8985
• Length: 421
• Species: Homo sapiens
• Alignment Length: 409
• Identity: 110/409 - (26%)
• Similarity: 179/409 - (43%)
• Gaps: 77/409 - (18%)

  Fly    14 ESGFWE----------------DFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRN 62
            :.|.||                |.|:.||..:...|::.:|.|..:..:|:.:.:...|..|:..
Human    41 DQGDWEDLACQKISYNVTDLAFDLYKELADLSQTSNVLVTPTSVAMAFAMLSLGTKADTRTEILE 105

  Fly    63 VLKFSENKT---LVANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAK 124
            .|..:..:|   .:...::.:|..|.|.:|.:.|...:.::|||...||..|.:..:|.:.::|.
Human   106 GLNVNLTETPEAKIHECFQQVLQALSRPDTRLQLTTGSSLFVNKSMKLVDTFLEDTKKLYHSEAS 170

  Fly   125 SIRLDDPVSASAIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIA 189
            ||...|...|...:|:::..||...:.::|  |....|||..||:.|.|.|:|...|||:...:.
Human   171 SINFRDTEEAKEQINNYVEKRTGRKVVDLV--KHLKKDTSLALVDYISFHGKWKDKFKAEHIMVE 233

  Fly   190 DFYVSANEIIPVKMMTLSASLLSGYIDDIDA-KIIELPYW--------NSTLSMRIILPNSVDGL 245
            .|:|....||.|.|:        .::...|. :..||..|        |:|..  .|||:. ..:
Human   234 GFHVDDKTIIRVPMI--------NHLGRFDIHRDRELSSWVLAQHYVGNATAF--FILPDP-KKM 287

  Fly   246 RKLKEKVGFIDYHLEK-------KSVNVKLPKFKIESKAQLKGIFENLGILDVFKPSADLNGLVL 303
            .:|:||:.:  .|||.       :|:|:..||..|....:||.:..||||..:|...|||:|:..
Human   288 WQLEEKLTY--SHLENIQRAFDIRSINLHFPKLSISGTYKLKRVLRNLGITKIFSNEADLSGVSQ 350

  Fly   304 ESGAKIDKIVQKAFLKIDEKGGEASAATGVLTRRKKSIDNLIQPPME---------FIADHPFFY 359
            |:..|:.|.|..|.|.|||||.||:.|                |.:|         .:.:.||..
Human   351 EAPLKLSKAVHVAVLTIDEKGTEATGA----------------PHLEEKAWSKYQTVMFNRPFLV 399

  Fly   360 VIHDNKVIY--FQGHIVEP 376
            :|.|:...:  |.|.:|.|
Human   400 IIKDDITNFPLFIGKVVNP 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_609128.2	serpin42Dd-like_insects	12..376	CDD:381070	109/407 (27%)
SERPINA2	NP_006211.2	serpinA2_PIL	56..418	CDD:381018	106/392 (27%)